Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain.

Brain Research Bulletin
Thomas Mueller, M F Wullimann

Abstract

NeuroD acts as one of the earliest transcription factors promoting differentiation in newborn neurons immediately after determination by neurogenin1 (ngn1). Here, we show the expression of neuroD in the 2 days postfertilization (dpf) zebrafish brain by in situ hybridization on sections. Generally, neuroD expressing cells lie one to several cell rows away from the ventricular surface, i.e., they seem to flank proliferative cells. However, most cells of the gray matter lie even more peripheral and are unstained. Highly specific local patterns of neuroD expressing cells are observed along the entire rostrocaudal zebrafish brain axis at that age with characteristic neuroD expression free zones (e.g., preoptic region and hypothalamus). Interestingly, these regions where neuroD expression is absent display a higher proliferative activity compared to neuroD-positive areas. To date it is an open question, whether this negative correlation of neuroD-expression and proliferation has a causal background.

References

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Citations

Jan 14, 2003·Brain Research. Developmental Brain Research·Thomas Mueller, Mario F Wullimann
Mar 18, 2003·Brain Research. Gene Expression Patterns·Mario F Wullimann, Thomas Mueller
Mar 18, 2008·Aquatic Toxicology·Elly Suk Hen ChowShuk Han Cheng
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Prisca ChapoutonLaure Bally-Cuif
Nov 3, 2011·Journal of Applied Toxicology : JAT·Jyotshna KanungoMerle G Paule
Feb 11, 2011·Developmental Neurobiology·Masahiko Hibi, Takashi Shimizu
Oct 15, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Giuseppina GarianoDaniela Zizioli
Aug 23, 2011·The Journal of Comparative Neurology·Julia GanzMichael Brand
Jul 29, 2004·The Journal of Comparative Neurology·Peter Hitchcock, Laura Kakuk-Atkins
May 9, 2006·Developmental Biology·Andres F SarrazinMiguel L Allende
Feb 12, 2014·Biochemical and Biophysical Research Communications·Makoto AokiHitoshi Okamoto
May 5, 2017·Development, Growth & Differentiation·Masahiko HibiYasunori Murakami
Jan 18, 2017·Scientific Reports·Carol BestMathilakath M Vijayan
Jun 24, 2004·The Journal of Comparative Neurology·Mario F Wullimann, Thomas Mueller
Apr 3, 2016·Journal of Neuroscience Research·Mirella Belleri, Marco Presta
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Luca MignaniDario Finazzi
Oct 20, 2006·Development·Ji Eun LeeRichard I Dorsky
Oct 18, 2021·Brain, Behavior and Evolution·Loreta MedinaEster Desfilis

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