Expression in bladder transitional cell carcinoma by real-time quantitative reverse transcription polymerase chain reaction array of 65 genes at the tumor suppressor locus 9q34.1-2: identification of 5 candidates tumor suppressor genes

International Journal of Cancer. Journal International Du Cancer
Najla AmiraOlivier Cussenot

Abstract

Frequent deletions on 9q34.1-2 were reported in bladder transitional cell carcinoma. High deletion mapping studies delimited a critical interval between markers D9S61 and D9S66, which is highly susceptible to contain a tumor suppressor gene. Expression level of the 65 genes localized in this region was analyzed by real-time quantitative RT-PCR, comparing tumor to normal urothelium. Five genes exhibited a significantly reduced expression level: C9orf9, KIAA0625, ABL1, LAMC3 and KIAA1857-netrin-G2, which exhibited the most significant downregulation (p=0.0007). KIAA1857-netrin-G2 belongs to the netrins and might then be a tumor suppressor gene in bladder cancer, as netrin1 receptor DCC has been implicated in tumorigenesis.

References

Jan 1, 1996·World Journal of Urology·C B WilsonR M Nakamura
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M LewisJ Y Wang
Jan 14, 1998·International Journal of Cancer. Journal International Du Cancer·A A Van TilborgE C Zwarthoff
Nov 7, 1999·Japanese Journal of Cancer Research : Gann·K OhgakiM Emi
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H Colognato, P D Yurchenco
Jul 19, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J LouhelainenK Hemminki
May 1, 2001·The Journal of Pathology·A A van TilborgE C Zwarthoff
Jan 24, 2002·Mechanisms of Development·Toshiaki NakashibaShigeyoshi Itohara
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Alain LatilOlivier Cussenot

❮ Previous
Next ❯

Citations

Nov 8, 2013·Nucleic Acids Research·Carsten A RaabeTimofey S Rozhdestvensky
Sep 26, 2007·Expert Review of Molecular Diagnostics·Xuewu Zhang
Mar 11, 2017·Journal of Proteome Research·Kevin BlackburnLawrence E Ostrowski
Nov 15, 2011·British Journal of Cancer·S E T LarkinC Aukim-Hastie
Apr 25, 2007·Autoimmunity·María-Carolina PáezJuan-Manuel Anaya
Mar 30, 2019·Journal of Nucleic Acids·Caroline Suzanne BruikmanJanine Maria van Gils
Mar 31, 2005·Revue neurologique·S GaillardD Bagnard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.