Expression in the placenta of neuronal markers for perinatal brain damage

Pediatric Research
Lia D E WijnbergerGerard H A Visser

Abstract

Determination of S-100 a and b and neuron-specific enolase (NSE) in (cord) blood and amniotic fluid has been used to assess neonatal neuronal damage after compromising conditions. However, these proteins are not only found in nervous tissue, and their expression in placenta and umbilical cord has never been investigated. In this study, S-100 (a and b) and NSE expression in human cord and placental tissue was studied by immunohistochemical analysis. Similar analysis was performed using two other brain-specific markers: glial fibrillary acidic protein and growth-associated protein B-50 (also known as GAP-43 or neuromodulin). Tissue was derived after elective cesarean section in seven women of different gestational ages after uncomplicated or complicated pregnancy. S-100 a and b and NSE immunoreactivity was found in several cell types and structures in the umbilical cord as well as in the placenta of all seven cases. Glial fibrillary acidic protein and B-50 showed no immunoreactivity. These data are of importance for interpreting findings of studies in which S-100 or NSE levels in cord blood or amniotic fluid have been related to neuronal damage in the neonate. The increased levels found may just as well be caused by leakage from ...Continue Reading

References

Feb 14, 1992·Biochemical and Biophysical Research Communications·Y EmotoH Hidaka
Jul 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·E KaiserW Worofka
Jan 1, 1985·Neuropathology and Applied Neurobiology·J A RoydsW R Timperley
Feb 28, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·K W BrownR J Thompson
May 1, 1995·Progress in Neurobiology·G FanòP Calissano
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jan 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·E ThornbergI Kjellmer
Jan 12, 1996·The Journal of Biological Chemistry·W S MailliardD D Schlaepfer
Jan 1, 1996·The Annals of Thoracic Surgery·S WestabyE Ståhl
Jun 25, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·K KintzelM Obladen
Mar 18, 1999·Advances in Experimental Medicine and Biology·L H AartsW H Gispen
Sep 16, 1999·Biochemical and Biophysical Research Communications·H InadaC W Heizmann
Jan 4, 2001·Journal of Cardiothoracic and Vascular Anesthesia·H JönssonS Blomquist
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·I Amer-WåhlinC Alling
Feb 24, 2001·Scandinavian Cardiovascular Journal : SCJ·P Johnsson

❮ Previous
Next ❯

Citations

Apr 1, 2004·Gene Expression Patterns : GEP·Nicolas Gonçalves-MendesVincent Sapin
Aug 21, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fabrizio Michetti, Diego Gazzolo
Sep 23, 2008·BMC Clinical Pathology·Sharon EinavYigal Shoshan
Oct 6, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sharon EinavEyal Itshayek
Feb 24, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laura D SerperoDiego Gazzolo
Dec 2, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mikko LoukovaaraSture Andersson
Feb 19, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Masao MurabayashiKensuke Harada
Dec 8, 2011·Journal of Neurochemistry·Fabrizio MichettiDiego Gazzolo
Oct 9, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Saadat Arif HuseynovaVafa Ilyas Yagubova
Jul 22, 2010·Seminars in Fetal & Neonatal Medicine·L BennetA J Gunn
Jan 3, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves GarnierDiego Gazzolo
Apr 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andrea SanniaDiego Gazzolo
Jul 25, 2006·International Review of Cytology·Julie Lafond, Lucie Simoneau
Apr 20, 2006·Arquivos de neuro-psiquiatria·Régis Osorio MartinsDiogo O Souza
Mar 2, 2018·American Journal of Reproductive Immunology : AJRI·Andrea Olmos-OrtizLorenza Díaz
Jan 11, 2022·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LapergolaDiego Gazzolo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.