Expression in vivo of CD45RA, CD45RB and CD44 on T cell receptor-transgenic CD8+ T cells following immunization

European Journal of Immunology
M PihlgrenJ Marvel

Abstract

We used mice transgenic for a major histocompatibility complex class I-restricted T cell receptor to study the changes of phenotype in vivo which follow priming by antigen of CD8 T cells. We show that following priming with peptide, CD44 on CD8 T cells is up-regulated. The change of phenotype was relatively stable, as primed CD8 cells isolated from thymectomized mice 6 weeks after priming still expressed increased levels of CD44. CD8 T cells in these mice are still responsive to peptide and could represent long-lived primed cells. No down-regulation in vivo of the CD45RA or CD45RB isoforms was found, indicating that there is a differential regulation of the expression of CD44 and CD45RB by activated CD8 transgenic T cells. These results contradict earlier studies in vitro which showed that CD8 T cells which have been primed earlier belong to the CD45RA- or CD45RB- subset.

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Citations

Jun 1, 1997·Current Opinion in Immunology·J Sprent
Jun 6, 2002·Immunology·Marion Berard, David F Tough
Dec 1, 1996·The Journal of Experimental Medicine·M PihlgrenJ Marvel
Jul 7, 1998·The Journal of Experimental Medicine·D H BuschE G Pamer
Jan 13, 2011·BMC Immunology·Karin GustafssonMichael Welsh
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·W C Kieper, S C Jameson
May 26, 1998·Journal of Neuroimmunology·B EngelhardtS A Michie
Mar 1, 1997·European Journal of Immunology·A WackD Kioussis
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiko WatanabeOsamu Yoshie

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