Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma

Annals of Surgical Oncology
Shinji YamamotoKatsuyuki Aozasa

Abstract

Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptosis and metastasis via activation of a nuclear factor-kappaB signaling pathway. Our previous study showed that the VCP expression level correlated with the disease recurrence rate and prognosis of patients with hepatocellular carcinoma and gastric carcinoma. This study was designed to evaluate the prognostic significance of VCP expression in non-small-cell lung carcinoma (NSCLC). VCP expression in 207 patients with NSCLC (133 men and 74 women) aged 35 to 78 years (median, 62 years) was examined by immunohistochemistry, in which staining intensity in tumor cells was categorized as weaker than (level 1) or equal to or stronger than (level 2) that in endothelial cells. Sixty-nine (33.8%) cases showed level 1 and 135 (66.2%) showed level 2 VCP expression. The frequency of the following was higher in patients with level 2 expression than in those with level 1 expression: male sex (P <.01), histological subtype of squamous cell carcinoma (P <.05), and smoking (P <.05). Patients with level 2 expression had poorer disease-free and overall survival rates (P <.05 and P <.01, respectively) than those with level 1 expression. Multivariate analysis...Continue Reading

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Jun 4, 2013·Cancer Letters·Delphine FessartEric Chevet
Jan 3, 2012·European Journal of Pharmacology·Krunoslav NujićVesna Eraković Haber
Sep 19, 2008·Journal of Cellular and Molecular Medicine·Neeraj Vij
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