Expression Levels of Semaphorins 3A, 3B, 4A, and 4D on Human Peri-implantitis

The International Journal of Oral & Maxillofacial Implants
Marta Ferreira BastosJamil Awad Shibli

Abstract

To evaluate the gene expression levels of semaphorins 3A, 3B, 4A, and 4D in both healthy and diseased implants. Subjects with peri-implantitis presented clinical attachment loss, probing depth ≥ 5 mm, bleeding on probing and/or suppuration, and radiographic bone loss > 4 mm. Peri-implant tissue biopsy specimens were sampled for analysis of the mRNA expression levels for semaphorins 3A, 3B, 4A, and 4D. A real-time polymerase chain reaction was performed, and the gene expression levels of semaphorins in relation to the housekeeping gene were analyzed by using the nonparametric Mann-Whitney test (P < .05). Thirty-five subjects (16 men, 19 women; mean age: 54.12 ± 2.34 years) with implant-supported restorations, using screw-shaped dental implants with internal or external hexagon were enrolled in this study. Higher levels of semaphorins 3A and 4D were detected in the peri-implantitis compared with the healthy tissues (P = .0011 and P = .0404, respectively), whereas Sem4A levels were significantly higher in the control group (P < .0001). Differences between groups in the expression levels of Sem3B were not significant. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of S...Continue Reading

Citations

Jul 1, 2020·Clinical Oral Investigations·Gabriela GiroJamil Awad Shibli
Oct 3, 2019·Brazilian Oral Research·Monica Grazieli CorrêaMarcio Zaffalon Casati
Oct 6, 2020·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Anmar KensaraRadi Masri
Dec 2, 2020·Biochemical Society Transactions·Liu WangDingming Huang

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