Abstract
The prognosis of oral squamous cell carcinoma (OSCC) patients is affected by tumor recurrence and metastasis, and cancer stem cells are hypothesized to be involved in these processes. Thus, the aim of the present study was to determine whether the expression levels of five stem cell-related transcription factors, sex determining region Y-box 2 (SOX2), octamer-binding transcription factor 4 (Oct4), avian myelocytomatosis viral oncogene homolog (c-Myc), Krüppel-like factor 4 (KLF4) and brachyury, are associated with metastasis and survival in OSCC. Immunohistochemistry was performed to analyze the expression of these proteins in biopsy specimens obtained from 108 OSCC patients. The results revealed that the expression of SOX2, Oct4, KLF4 and brachyury were significantly associated with lymph node metastasis (P=0.002, P=0.031, P=0.003 and P=0.007, respectively). In addition, the expression of KLF4 and brachyury were significantly associated with distant metastasis (P=0.014 and P=0.012, respectively). Furthermore, multivariate analysis revealed that SOX2 and KLF4 are predictive factors for lymph node metastasis [odds ratios (ORs), 4.526 and 4.851, respectively], and KLF4 is also a predictive factor for distant metastasis (OR, 9.607...Continue Reading
References
Mar 1, 1986·Journal of Oral Pathology·G AnnerothS Silverman
Sep 15, 1994·Genes & Development·A KispertR Reuter
Nov 2, 2001·Nature·T ReyaI L Weissman
Mar 6, 2003·Oral Oncology·Eric M GendenCrispian Scully
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ashka Y PandyaJ Michael Ruppert
May 4, 2005·Trends in Neurosciences·Vasso Episkopou
Aug 3, 2005·Nature Reviews. Molecular Cell Biology·Sovana Adhikary, Martin Eilers
Aug 15, 2006·Cell·Kazutoshi Takahashi, Shinya Yamanaka
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Paul M Evans, Chunming Liu
Jun 23, 2009·Development·Ian Chambers, Simon R Tomlinson
Jan 15, 2010·The Journal of Clinical Investigation·Romaine I FernandoClaudia Palena
May 14, 2010·Japanese Journal of Clinical Oncology·Xueyan ZhangQianggang Dong
Jun 16, 2010·Cardiovascular Research·Shinji KaichiToshio Heike
Jul 16, 2010·The American Journal of Surgical Pathology·Lynette M ShollJason L Hornick
Aug 12, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nilesh V PatelVincent W Yang
Jan 12, 2011·Cancer Science·Shyh-Kuan TaiShie-Liang Hsieh
Feb 1, 2011·BMC Cancer·Claudia LengerkeAnnette Staebler
Dec 16, 2011·BMC Cancer·Jens NeumannAndreas Jung
Mar 1, 2012·World Journal of Gastroenterology : WJG·Wei HeQing-Xia Fan
May 23, 2012·PloS One·Si ChenNa Li
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hiroshi KitamuraTaiji Tsukamoto
Aug 31, 2012·BMC Cancer·Miyuki ShimodaKanemitsu Shirasuna
Oct 19, 2012·International Journal of Oncology·Ikumi ImajyoYoshihide Mori
Jan 12, 2013·Medical Oncology·Jun RuanHuan Cheng
Feb 19, 2013·Cellular Signalling·Kuancan LiuXiaopeng Lan
May 7, 2013·Oral Oncology·M A González-MolesJ J Plaza-Campillo
Oct 10, 2013·Medical Oncology·Li-Sung HsuMaw-Soan Soon
Feb 8, 2014·International Journal of Oncology·Yosuke KobayashiYoshihide Mori
Mar 25, 2014·Medical Oncology·Mohammad Mahdi ForghanifardMohammad Reza Abbaszadegan
Jun 10, 2014·Nature·Soufiane BoumahdiCédric Blanpain
Oct 22, 2014·International Journal of Biological Sciences·Bing-Jia ChenWen Zhang
Nov 7, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Shanaya Saurin PatelRakesh Mahesh Rawal
Apr 2, 2015·Oncotarget·Alice NomuraAshok K Saluja
Citations
Jun 26, 2018·Oral Diseases·Suelen Teixeira LuizAline Cristina Batista Rodrigues Johann
Jan 21, 2017·F1000Research·Carl YoussefCarlos A Bagley
May 2, 2020·Journal of Cellular Physiology·Lusha LiZhongjian Xie
Nov 29, 2017·Molecular and Clinical Oncology·Jihad KaramElie Hadchity
Jun 13, 2019·Oncology Letters·Song-Hee HanEun Shin
Jan 8, 2019·Cancer Biomarkers : Section a of Disease Markers·Dongliang HouLi Chen
Aug 2, 2019·World Journal of Clinical Oncology·Arslaan Javaeed, Sanniya Khan Ghauri
Jul 23, 2020·Frontiers in Oncology·Ming ChenJun Shen
Mar 5, 2021·Oral Diseases·Marcos Antonio Pereira de LimaSilvia Helena Barem Rabenhorst
Mar 25, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ismail S MohiuddinMin H Kang
Jun 8, 2021·Cancer Biomarkers : Section a of Disease Markers·María Luisa PaparellaAna Rosa Raimondi
Dec 7, 2021·Oncology Letters·Cong XuHai-Ying Chen