Expression of 17β-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Bartosz Adam FryczPaweł Piotr Jagodziński

Abstract

In most populations, gastric cancer (GC) incidence is higher in men than in women, which may suggest the role of sex steroid hormones in gastric cancerogenesis. Both, androgens and estrogens can be synthetised in peripherial tissues. This process is controlled by expression of steroidogenic enzymes. Therefore, we evaluate the 17β-hydroxysteroid dehydrogenase type 2 (HSD17B2) transcript and protein levels in gastric tumoral and nontumoral tissue. We also determined the association between HSD17B2 transcript and protein levels and some clinicopathological features in GC. We found significantly decreased levels of HSD17B2 transcript (P=0.00072) and protein (P=0.00017) in primary tumoral tissues of GC patients, as compared to nontumoral tissues. In patients above 60 years of age the amounts of HSD17B2 transcript (P=0.00044) and protein (P=0.00027) were significantly lower in tumoral than nontumoral tissues. Similarly, lower HSD17B2 levels, both in terms of the transcript and protein, were observed in tumoral tissues of male (P=0.013, P=0.0014), patients stomach (P=0.0062, P=0.045) and cardia (P=0.02, P=0.02) site of tumor, T3 (P=0.018, P=0.014) depth of invasion, N0 (P=0.017, P=0.045) lymph node metastasis, G3 (P=0.0027, P=0.014) m...Continue Reading

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Citations

Mar 29, 2016·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Bartosz Adam FryczPaweł Piotr Jagodziński
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M WesołowskaP P Jagodziński
May 20, 2017·Oncology Letters·Bartosz Adam FryczPaweł Piotr Jagodziński
Sep 13, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Chen-Yan ZhangSheng-Xiang Lin

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Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Bartosz Adam FryczPaweł Piotr Jagodziński
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