PMID: 11916131Mar 28, 2002Paper

Expression of 36-kDa microfibril-associated glycoprotein (MAGP-36) in human keratinocytes and its localization in skin

Journal of Dermatological Science
Eiichi HiranoKouji Okamoto

Abstract

Microfibril-associated glycoprotein-36 (MAGP-36) is a recently isolated elastin-binding protein and considered to be a member of microfibril-associated glycoproteins (MAGPs). We studied the expression of MAGP-36 in cultured normal human keratinocytes and its localization in the skin. MAGP-36 was found to be expressed in cultured human keratinocytes by Western blot and RT-PCR assays. The levels of MAGP-36 (polypeptide and mRNA) and the number of MAGP-36-producing keratinocytes were greatly increased during Ca(2+)-induced differentiation of keratinocytes. Immunohistochemical studies demonstrated that MAGP-36 colocalized with elastic fibers and formed candelabra like-fibers in the superficial dermis of normal skin. In the elderly skin of sun-exposed region, immunoreactivity of MAGP-36 in the superficial dermis disappeared. In the lesional skin of pseudoxanthoma elasticum which is an elastin-related disorder, immunoreactivity of MAGP-36 was found in the accumulation of disintegrated elastic fibers. The results show that MAGP-36 is a component of elastic fibers in the dermis and co-operates with elastin in normal and diseased conditions.

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Citations

Aug 22, 2013·Expert Reviews in Molecular Medicine·Andrew K BaldwinCay M Kielty
Mar 31, 2006·Journal of Medical Genetics·P N RobinsonM Godfrey
Jan 29, 2013·Drug Delivery and Translational Research·Balakrishnan SivaramanAnand Ramamurthi
Nov 14, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Anders SchlosserGrith L Sorensen
Jun 3, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anne Trommelholt HolmGrith Lykke Sorensen
May 27, 2021·Biomarker Insights·Susanne Gjørup SækmoseGrith Lykke Sorensen

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