PMID: 9178857May 9, 1997Paper

Expression of 5-HT7 receptor mRNA in rat brain during postnatal development

Neuroscience Letters
M L VizueteJ Cano

Abstract

The present study is the first one to demonstrate the expression of 5-HT7 receptor mRNA by in situ hybridization during postnatal development. No quantitative developmental changes in the 5-HT7 gene expression was observed in neocortex, pyramidal layers of CA1 and CA2, dentate gyrus, most of thalamic nuclei, mammillary region, superior colliculus and central gray. However, in retrosplenial cortex, subiculum and medial habenula an increase of labeling is observed between postnatal days (PN) PN15 and PN21. Striatum showed a transient expression during the first stages of development to be undetectable in adults. CA3 pyramidal cell layer, intramediodorsal thalamic nucleus and lateral habenula displayed a high mRNA expression at PN5 and PN8 which decreased throughout development but it was still present in adults. A possible non-neurotransmitter trophic function of 5-HT mediated through 5-HT7 receptors could be suggested.

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Citations

Dec 9, 2003·Trends in Molecular Medicine·Diethelm W RichterEvgeni Ponimaskin
Dec 14, 2002·Brain Research. Developmental Brain Research·Patricia LaplanteMichael J Meaney
Apr 25, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Katsumasa T Muneoka, Morikuni Takigawa
Jan 27, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katsunori KobayashiHidenori Suzuki
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ian C HellstromMichael J Meaney
Dec 26, 2001·Neuropharmacology·Catherine H GillCeri H Davies
May 24, 2011·Neuroscience and Biobehavioral Reviews·Heather C Brenhouse, Susan L Andersen
Mar 1, 2008·Behavioural Brain Research·Antonella GasbarriAlfredo Meneses
Jan 16, 2007·Pharmacology, Biochemistry, and Behavior·Fulton CrewsClyde Hodge
Feb 12, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Susan L Andersen, Carryl P Navalta
Nov 9, 2016·Frontiers in Synaptic Neuroscience·Anna TchenioManuel Mameli
Feb 15, 2005·Brain Research. Developmental Brain Research·Antonella RussoStefania Stanzani
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Susan L Andersen, Carryl P Navalta
Jul 21, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jimmy OlusakinPatricia Gaspar
May 22, 2017·Pharmacology, Biochemistry, and Behavior·Martin MetzgerLeandro B Lima
Dec 4, 2003·Brain Research·Krzysztof TokarskiGrzegorz Hess
Oct 19, 2017·Journal of Medicinal Chemistry·Enza LacivitaMarcello Leopoldo
Feb 5, 2008·Behavioural Brain Research·Agata CifarielloAntonella Gasbarri

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