Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis

Oncogene
A KurtzA Wellstein

Abstract

Fibroblast growth factors (FGF)-1 and -2 are found in most embryonic and adult normal and tumor tissues, where they are immobilized in the extracellular matrix (EM). Mobilization of these FGFs is part of a tightly controlled process resulting in the activation of high-affinity receptors. Recently, we have shown that a novel human FGF-binding protein (FGF-BP) mediates the release of immobilized FGF-2 from the EM. Here we isolated genomic and cDNA clones of the mouse FGF-BP homologue and studied its expression during embryonic development and skin carcinogenesis. The murine gene contains two exons that generate a 1.2 kb mRNA and predicts an 18 kDa secreted protein that is 63% identical to its human homologue. FGF-BP mRNA expression during embryogenesis is restricted to skin, intestine and lung. In the developing skin, FGF-BP expression starts at embryonic day 9, reaches peak levels perinatally and is downregulated during postnatal development. Development regulation in the intestine is similar, but in lungs and ovaries high expression was also observed in the adult. FGF-BP mRNA expression in the adult skin is dramatically increased during early stages of carcinogen-induced transformation in vivo and by ras-activation in vitro. Fi...Continue Reading

Citations

Sep 23, 2009·Archives of Otolaryngology--head & Neck Surgery·Weimin LiJizhen Lin
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·K NakanishiA Hakura
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·E R SauterM Herlyn
Apr 17, 2010·Molecules and Cells·Hae-ock LeeJhingook Kim
Aug 2, 2008·The Journal of Biological Chemistry·Wentao ZhangAnton Wellstein
Oct 28, 2014·The Journal of Clinical Investigation·William M GordonBogi Andersen
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Andreas KurtzAnton Wellstein
Jun 7, 2008·Animal Reproduction Science·L ZhangN Li
Dec 6, 2005·The International Journal of Biochemistry & Cell Biology·Shaker AbuharbeidAchim Aigner
Sep 21, 2010·Molecular and Cellular Neurosciences·Yasunari YamanakaToshio Heike
Jan 1, 2013·Computational and Structural Biotechnology Journal·Malek KammounIsabelle Cassar-Malek
Sep 29, 2011·The American Journal of Pathology·Elena TassiAnton Wellstein
Apr 5, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kevin McDonnellAnton Wellstein
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elena TassiAnton Wellstein
Aug 18, 2001·The Journal of Biological Chemistry·E TassiA Wellstein
Jan 20, 2001·The Journal of Biological Chemistry·M MongiatR V Iozzo
Sep 4, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Donna R NewmanPhilip L Sannes
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Krissa A GibbyAnton Wellstein
Jul 26, 2011·Journal of Cutaneous Medicine and Surgery·Yong HuangXu-Sheng Liu
Dec 31, 2020·Circulation Research·Maarja A MäeChrister Betsholtz
Jan 1, 2021·Analytical Cellular Pathology (Amsterdam)·Wenjing ZhangHui Wang
Mar 4, 2006·Methods : a Companion to Methods in Enzymology·Ralf T HenkeAnton Wellstein

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