PMID: 6169997Oct 29, 1981Paper

Expression of a human gene for interferon in yeast

Nature
R A HitzemanB D Hall

Abstract

A DNA sequence coding for mature human leukocyte interferon D (LeIF-D) was linked with DNA fragments of the 5'-flanking sequences of the Saccharomyces cerevisiae (yeast) alcohol dehydrogenase I gene in a plasmid capable of autonomous replication and selection in both yeast and Escherichia coli. Yeast cells transformed by these plasmids synthesize up to 1 x 10(6) molecules of biologically active LeIF-D per cell.

References

Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A HinnenG R Fink
Nov 1, 1979·Nature·D T StinchcombR W Davis
Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K BackmanW Gilbert
Jan 1, 1975·Methods in Cell Biology·S C Kuo, S Yamamoto
Jan 1, 1981·Nature·S HenikoffK A Nasmyth
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G FayeM Smith
Jan 1, 1980·Annual Review of Biochemistry·T D Petes

❮ Previous
Next ❯

Citations

Jul 1, 1990·Current Genetics·P DurrensM Aigle
Dec 1, 1982·Current Genetics·G ReipenC P Hollenberg
Jan 1, 1985·Current Genetics·J B McNeilM Smith
Nov 28, 2012·Applied Microbiology and Biotechnology·Eric A Johnson
Jun 1, 1995·Pharmacology & Therapeutics·M A Horisberger, S Di Marco
Dec 1, 1992·Trends in Biotechnology·G GellissenC P Hollenberg
Jan 1, 1984·Gene·C G GoffA Taunton-Rigby
Jan 1, 1983·Biotechnology Advances·J D Friesen, G An
Jan 1, 1983·Biotechnology Advances·S Scheinbach
Jan 1, 1989·Cellular Signalling·D EngelbergA Levitzki
Dec 1, 1990·Current Opinion in Biotechnology·G T Yarranton
Apr 6, 2004·Journal of Biotechnology·Annamaria MericoConcetta Compagno
Aug 1, 1993·Bio/technology·J M CreggW C Raschke
Nov 1, 1991·Bio/technology·R G Buckholz, M A Gleeson
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E De MaeyerK Atherton
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A MiyanoharaK Matsubara
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G L McKnight, B L McConaughy
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D VetterP D Sadowski
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P K Chanda, H F Kung
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R A KramerS Hilliker
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T CabezónA Bollen
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E JayM Dawood
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J H CramerJ L Slightom
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A JabbarD P Nayak
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D Z Wen, M J Schlesinger
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M MakarowL Kääriäinen
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T L Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.