PMID: 8614558Nov 17, 1995Paper

Expression of a MADS box gene, MEF2D, in neurons of the mouse central nervous system: implication of its binary function in myogenic and neurogenic cell lineages

Neuroscience Letters
H IkeshimaT Takano

Abstract

MEF2D, a member of myocyte-specific enhancer binding factor 2 (MEF2) gene family, was shown by Northern blot hybridization to be strongly expressed in the head portion of mouse embryos at later stages of ontogenesis, in the cerebellum and the cerebrum of adult mice, in cultured cell lines of neuronal origin, and in skeletal and cardiac muscles. During ontogenesis, MEF2D transcripts were detected by in situ hybridization in the olfactory bulb, entorhinal cortex, pyriform cortex, and hippocampus, in Purkinje and granule cells, and in large neurons in both the ventral and dorsal horns of spinal cord. Adult mice continued to express MEF2D in these limited areas of the central nervous system. Thus, MEF2D seems to be involved in either the differentiation process or the function of these neurons.

References

Jul 11, 1970·Nature·J P JacobsJ P Baille
Jul 26, 1968·Science·P BendaW Sweet
Mar 1, 1994·Molecular and Cellular Biology·J F MartinE N Olson
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·B LillyE N Olson
Apr 1, 1993·Molecular and Cellular Biology·J C McDermottB Nadal-Ginard
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J F MartinE N Olson

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Citations

Sep 24, 1999·The Journal of Comparative Neurology·S M FarrisS E Fahrbach
Feb 25, 1998·Biochimica Et Biophysica Acta·M OgawaS Aiso
Nov 27, 2002·Progress in Neurobiology·Eiichi HinoiYukio Yoneda
Jan 19, 1999·Annual Review of Cell and Developmental Biology·B L Black, E N Olson
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Florence J BlanchardJustin Blau
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Nazanin MajdzadehSantosh R D'Mello
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shu-ichi OkamotoStuart A Lipton
Jun 25, 2013·Genes, Brain, and Behavior·A J RashidS A Josselyn
Oct 3, 2018·Molecular Neurobiology·Sandhya Prakash Kamath, Albert I Chen
Jan 7, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Haiming YuanXiaoli Chen
Oct 26, 2007·Development·Matthew J Potthoff, Eric N Olson

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