Expression of a membrane form of the pregnancy-associated protein TJ6 on lymphocytes

Cellular Immunology
T C NicholsK Beaman

Abstract

TJ6 is a novel protein which has immunosuppressive activity and may have a functional role in fetal allograft survival during pregnancy. Initial studies indicated that when mice were treated with an anti-TJ6 binding mAb early in pregnancy, the pregnancies were completely ablated and that TJ6 expression is enhanced dramatically during pregnancy. In addition we have cloned the cDNA for TJ6 which encodes a possible transmembrane domain that may include six to seven transmembrane regions. Therefore, we examined TJ6 expression on PBL of pregnant and non-pregnant women and found that TJ6 is expressed primarily on CD19+ B cells from pregnant but not nonpregnant women. TJ6 was not expressed on CD3+ lymphocytes from either group but was expressed on CD56+ cells from a small population of pregnant women which preliminary data indicate may correlate with the occurrence of spontaneous abortion in these women. Here we also show that TJ6 transcripts are highly expressed in the developing fetoplacental unit as well as in the developing thymus. We also begin to characterize the expression of TJ6 isoforms in an acute lymphocytic leukemia cell line (SB), murine thymus, and the developing murine fetoplacental unit, as well as the expression of a ...Continue Reading

Citations

Jan 20, 1999·Immunology and Cell Biology·H Morton
Jan 5, 2013·The Journal of Biological Chemistry·Hiroyuki HosokawaVladimir Marshansky
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·A ChedidK D Beaman
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·J H CheckJ Szekeres-Bartho
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·M Mandal, K D Beaman
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·C B CoulamD A Clark
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·F S MeraliD A Clark
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·K BeamanA Gilman-Sachs
Dec 1, 1995·American Journal of Reproductive Immunology : AJRI·J Szekeres-BarthoP Varga
May 21, 2005·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·J A KangK D Beaman
Sep 11, 2004·Clinical and Diagnostic Laboratory Immunology·Richard A Derks, Kenneth D Beaman
Oct 1, 1995·American Journal of Reproductive Immunology : AJRI·C B Coulam, K D Beaman
Nov 5, 1999·Clinical and Diagnostic Laboratory Immunology·T S GivensK D Beaman
Mar 6, 1999·Clinical and Diagnostic Laboratory Immunology·B K DuChateauK D Beaman

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