PMID: 8951791Oct 1, 1996Paper

Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis

Mechanisms of Development
E DevicY Audigier

Abstract

In order to determine whether G protein-coupled receptors play a role in early embryogenesis, we looked for cDNA fragments amplified between primers located in consensus sequences of transmembrane segments. Using one such amplified fragment as a probe, we cloned a novel member of the G protein-coupled receptor superfamily in Xenopus. Alignment of the deduced protein sequence with that of other receptors discloses some homology with angiotensin receptors. A single transcript of 2.5 kb is detected at the late blastula stage and its expression increases during gastrulation. In situ hybridization reveals transcripts initially in the ventrolateral involuting marginal zone and later in the lateral plate mesoderm. At larval stages, the transcript is expressed in procardiac tube and forming blood vessels, where it is localized in the inner endothelial layer. Thus, this gene traces an endothelial lineage and represents a very early and unique marker in Xenopus of the specification of cardiac and vascular endothelia. We propose the name of X-msr for mesenchyme-associated serpentine receptor.

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Citations

Jan 10, 2002·Biochemical and Biophysical Research Communications·Bernard MasriYves Audigier
Dec 18, 2003·Gene Expression Patterns : GEP·Shana R Fawcett, M W Klymkowsky
Jun 9, 2004·Gene Expression Patterns : GEP·Lance A DavidsonDouglas DeSimone
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Jun 17, 2009·Journal de la Société de biologie·Bernard MasriYves Audigier
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Sep 11, 2007·Molecular and Cellular Endocrinology·Mi Jin MoonJae Young Seong
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Mar 11, 2009·Developmental Biology·Ke XuOndine Cleaver

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