PMID: 6967342May 1, 1980Paper

Expression of a non-T, non-B ALL associated antigen on leukemic cells, lymphoblastoid cell lines and normal blood cells

Blut
H Winterleitner

Abstract

Two of our preparations of rabbit immune sera against Non-T, Non-B ALL cells were characterized. After a previously described absorption schedule used at present with some modifications, the sera were tested by indirect immunofluorescence and by a complement-dependent microcytotoxicity technique on a panel of cells: various types of ALL, lymphoblastoid cell lines of T, B and Non-T, Non-B surface characteristics, other leukemias (AML, CLL, Ph1 positive CML-BC), nonleukemic tissue of normal bone marrow, lymph-nodes and tonsils and also PBL. About 70% of Non-T, Non-B ALL, the Non-T, Non-B ALL line "REH" and CML cells in Ph1 positive "lymphoid" blast crisis were reactive in both test systems. Non-regenerating normal bone marrow, peripheral blood lymphocytes, and lymph node cells were non-reactive. CLL cells and tonsil cels, however, showed a positive fluorescence, yet gave a negative reaction in the complement-dependent microcytotoxicity test. This phenomenon might be explained by unspecific binding to Fc receptors. The antisera thus appear to detect a common Non-T, Non-B ALL antigen.

References

Nov 1, 1977·British Journal of Haematology·G JanossyK Welsh
Jul 1, 1979·Blut·W RellaW Knapp
Mar 15, 1976·International Journal of Cancer. Journal International Du Cancer·H SteinG Landbeck
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S F SchlossmanJ L Strominger
May 1, 1975·Clinical Immunology and Immunopathology·M F GreavesT A Lister

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.