PMID: 9539124Apr 16, 1998Paper

Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex

Neuron
Chris I De ZeeuwJohn Oberdick

Abstract

Cerebellar long-term depression (LTD) is a model system for neuronal information storage that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed to underlie several forms of cerebellar motor learning. Previous studies using various knockout mice (mGluR1, GluRdelta2, glial fibrillary acidic protein) have supported this claim; however, this work has suffered from the limitations that the knockout technique lacks anatomical specificity and that functional compensation can occur via similar gene family members. To overcome these limitations, a transgenic mouse (called L7-PKCI) has been produced in which the pseudosubstrate PKC inhibitor, PKC[19-31], was selectively expressed in Purkinje cells under the control of the pcp-2(L7) gene promoter. Cultured Purkinje cells prepared from heterozygous or homozygous L7-PKCI embryos showed a complete blockade of LTD induction. In addition, the compensatory eye movements of L7-PKCI mice were recorded during vestibular and visual stimulation. Whereas the absolute gain, phase, and latency values of the vestibulo-ocular reflex and optokinetic reflex of the L7-PKCI mice were normal, their ability to adapt their vestibulo-ocular reflex gain during visuo-vestibu...Continue Reading

References

Nov 2, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MarianiC Sotelo
Oct 11, 1979·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K W Caddy, T J Biscoe
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A KonnerthG J Augustine
Apr 1, 1992·The Journal of Cell Biology·W C WetselY A Hannun
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N LeclercM Yamamoto
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Sakurai
Mar 1, 1990·Brain Research. Developmental Brain Research·F L HuangK P Huang
Jan 1, 1989·Annual Review of Neuroscience·M Ito
Apr 1, 1989·Journal of Cellular Biochemistry·F L HuangK P Huang
Nov 4, 1988·Science·S G Lisberger
Jun 1, 1995·Molecular and Cellular Neurosciences·R J SmeyneJ Oberdick
Dec 1, 1995·The Journal of Biological Chemistry·A C Newton
Jan 1, 1995·Annual Review of Neuroscience·D J Linden, J A Connor
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·E HummlerG Schütz
Sep 1, 1993·Neuroscience·S Chen, D E Hillman
Jan 1, 1993·Experimental Brain Research·T T KhaterB W Peterson
May 24, 1996·Science·J L RaymondM D Mauk

❮ Previous
Next ❯

Citations

Sep 25, 1999·Journal of Cellular Physiology·C BrennerK Huebner
Oct 31, 2000·The Journal of Comparative Neurology·N H BarmackJ Yoshimura
Jul 3, 2013·Cellular and Molecular Life Sciences : CMLS·Kouichi Hashimoto, Masanobu Kano
Feb 22, 2011·Experimental Brain Research·Dianne M BroussardDavid R Hampson
May 24, 2006·Journal of the Association for Research in Otolaryngology : JARO·Daniel R Calabrese, Timothy E Hullar
May 14, 2008·Journal of the Association for Research in Otolaryngology : JARO·David M LaskerLloyd B Minor
Oct 25, 2007·Brain Cell Biology·Elisabeth M AloyMartin E Schwab
Sep 5, 2008·The Cerebellum·Rui ZhangJohn Oberdick
Oct 7, 2011·The Cerebellum·Elizabeth A FinchGeorge J Augustine
Apr 15, 2004·Molecular and Cellular Neurosciences·Christopher R BrodieLinda M Boland
Apr 22, 2004·Neuroscience Research·Tomoya Sakatani, Tadashi Isa
Feb 21, 2004·Neuropharmacology·Andrea L BaumanJohn D Scott
Dec 20, 2000·Brain Research·M Ito
Aug 11, 2000·Journal of Neuroscience Methods·J S StahlC I De Zeeuw
Sep 15, 1998·Trends in Neurosciences·H DanielF Crépel
Sep 15, 1998·Trends in Neurosciences·C I De ZeeuwT J Ruigrok
Feb 19, 2002·Neuroscience Research·Fumihiro ShutohSoichi Nagao
Jan 22, 2000·Brain Research Bulletin·M Ito
Jan 23, 1999·Current Opinion in Neurobiology·T J Ebner
Jan 23, 1999·Current Opinion in Neurobiology·J L Raymond
Sep 1, 1998·Trends in Cognitive Sciences·D M WolpertM Kawato
Sep 1, 1998·Trends in Cognitive Sciences·M Ito
Apr 24, 2003·Behavioral Neuroscience·John H FreemanNorma T DiPietro
Dec 15, 2010·Nature Cell Biology·Wolfgang WagnerJohn A Hammer
Dec 15, 2010·Nature Cell Biology·Michael Stiess, Frank Bradke
Sep 2, 2005·Nature Neuroscience·Eric BurguièreLaure Rondi-Reig
Jun 19, 2010·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
May 6, 2011·Nature Reviews. Neuroscience·Chris I De ZeeuwSebastiaan K Koekkoek
Aug 17, 2012·Nature Reviews. Neuroscience·Zhenyu GaoChris I De Zeeuw
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami Citri, Robert C Malenka
Aug 24, 2002·The European Journal of Neuroscience·A M van Alphen, C I De Zeeuw
Jan 6, 2000·The New England Journal of Medicine·P Sillevis SmittR Shigemoto
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·John T WeberChristian Hansel
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Rinaldo, Christian Hansel
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Romain LyAnne Feltz
Mar 1, 2000·Network : Computation in Neural Systems·J D Victor

❮ Previous
Next ❯

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