Expression of a public idiotype by human monoclonal IgM directed to myelin-associated glycoprotein and characterization of the variability subgroup of their heavy and light chains.

The Journal of Experimental Medicine
J C BrouetE Mihaesco

Abstract

Most studies using rabbit or mouse antisera failed to detect CRI between human IgM directed to MAG. We show here that 9 of 10 such IgM express a public CRI as defined by a nonhuman primate antiserum. Shared idiotype is likely involved in (or close to) the combining site of those IgM since antiidiotypic serum inhibited the binding of IgM to MAG and reacted with IgM having different variable regions of light and heavy chains. Partial aminoterminal sequence of heavy and light chains showed that anti-MAG IgM use either lambda chains (one IgM) or kappa light chains (six IgM) of different variability subgroups (V kappa IV in three instances, V kappa I in two, and V kappa II in one), whereas heavy chains belong to the VHIII (six IgM) or to the VHII (1 IgM) subgroup. These features distinguish these IgM from other human monoclonal IgM with a defined antibody activity, such as rheumatoid factors or cold agglutinins.

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Citations

Jan 1, 1992·International Journal of Clinical & Laboratory Research·J C BrouetA Tsapis
Nov 6, 1990·Journal of Immunological Methods·M O JauberteauJ L Preud'homme
Nov 1, 1992·Leukemia & Lymphoma·G Dighiero
Jan 1, 1991·Leukemia & Lymphoma·G Dighiero, L Borche

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