PMID: 7541394Jul 4, 1995Paper

Expression of acid cysteine proteinase inhibitor (ACPI) in the normal human prostate, benign prostatic hyperplasia and adenocarcinoma

International Journal of Cancer. Journal International Du Cancer
K O SöderströmA Rinne

Abstract

Acid cysteine proteinase inhibitor (ACPI or cystatin A) is a protein (12 kDa) which inhibits the action of several cysteine proteinases, e.g. cathepsins B, H, L and S. In this study the cellular location of ACPI has been immunohistochemically investigated in the normal human prostate, in benign prostatic hyperplasia (BPH) and in adenocarcinoma. ACPI was found in the basal epithelial cells of the normal prostate. The secretory epithelial cells did not express ACPI. In the hyperplastic prostate, the expression of ACPI was decreased and it was also expressed more focally in the basal cells. Hyperplastic basal cells also expressed ACPI. In prostatic adenocarcinoma, no ACPI expression was found. The absence of ACPI expression was obvious and if the sections contained both benign and malignant cells, only the benign glandular structures always expressed ACPI. The results suggest that expression of ACPI might be related to prostatic epithelial cell proliferation and differentiation. Possibly the detection of ACPI in tissue sections might be helpful in identifying prostatic adenocarcinoma, especially in cases with small carcinomatous foci.

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Citations

Feb 7, 2013·Journal of Cancer·Spela Magister, Janko Kos
Jan 27, 2004·The American Journal of Pathology·Daotai NieKenneth V Honn
Mar 17, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pål VoltersvikBirgitta Asjö
Jan 10, 2013·Korean journal of urology·Kwangsu ParkHyun Woo Kim
May 21, 2019·Journal of Biomolecular Structure & Dynamics·Fakhra AminBilqees Bano
Oct 10, 2003·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R Colella, S F Casey
Feb 1, 1996·Biological Chemistry Hoppe-Seyler·Y M HenskensA V Nieuw Amerongen
Jun 30, 2004·Journal of Andrology·Thomas JibornAnders Bjartell

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