PMID: 7544700May 26, 1995Paper

Expression of acidic FGF mRNA in rat auditory brainstem during postnatal maturation

Brain Research. Developmental Brain Research
L LuoA F Ryan

Abstract

In situ hybridization was used to investigate the mRNA distribution of acidic and basic fibroblast growth factor (aFGF and bFGF) in the auditory brainstem of neonatal and adult rats. bFGF mRNA was not detected at any age. In adult rats, aFGF mRNA was strongly expressed in the principal neurons of the anteroventral and posteroventral cochlear nuclei, but not in the octopus cells. In the dorsal cochlear nucleus, aFGF mRNA was seen only in scattered smaller vertical cells. aFGF was strongly expressed in the nucleus of the trapezoid body and in all periolivary cell groups, but not in the medial and lateral olivary nuclei. No expression was observed in the lemniscal nuclei or in the central nucleus of the inferior colliculus, but large neurons in the external zone of the colliculus were labeled. Developmentally, low levels of aFGF expression appeared in the cochlear nuclei and olivary nuclei between P0 and P6. This expression increased rapidly during the onset of hearing, between P10 and P14, and reached adult level by P14-P17. Labeling in collicular neurons appeared slightly later. The results suggest that the appearance of strong aFGF mRNA expression is related to the onset of function.

References

Apr 1, 1991·Trends in Pharmacological Sciences·C J Robinson
Aug 27, 1991·Biochimica Et Biophysica Acta·D E Sullivan, T G Storch
Apr 24, 1991·Brain Research. Developmental Brain Research·D ThomasB Boilly
Jan 1, 1991·Experimental Brain Research·M M GiacobiniL Olson
Jan 1, 1991·Annals of the New York Academy of Sciences·J W McAvoyF J Lovicu
Dec 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H A Simmons, L G Raisz
Mar 8, 1991·The Journal of Comparative Neurology·C GrotheK Unsicker
Apr 11, 1990·Nucleic Acids Research·A IsacchiP Sarmientos
Sep 1, 1990·Molecular and Cellular Biology·D E JohnsonL T Williams
Apr 11, 1989·Nucleic Acids Research·S P GoodrichP E Mansson
Apr 1, 1989·British Medical Bulletin·A Baird, P A Walicke
Jun 1, 1989·Plastic and Reconstructive Surgery·P G CordeiroR Madison
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·D Gospodarowicz
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P WalickeR Guillemin
Mar 1, 1986·Journal of Comparative Psychology·J B Kelly, M Potash
Feb 10, 1981·The Journal of Comparative Neurology·B A Rogowski, A S Feng

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Citations

Jun 8, 2002·Annual Review of Neuroscience·Edwin W Rubel, Bernd Fritzsch
Mar 27, 2003·Neurosurgery·Tetsuji SekiyaShigeharu Suzuki
Feb 6, 1999·The Journal of Comparative Neurology·R L Saint MarieA F Ryan
Sep 2, 1998·The Journal of Comparative Neurology·W J Clerici, J R Coleman
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Phillip L Marzella, Lisa N Gillespie

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