PMID: 24351917Dec 20, 2013Paper

Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma

Journal of Oral Science
Yuji MiyazakiKaoru Kusama

Abstract

Oral epithelial dysplasia is thought to be a precursor state of carcinogenesis and may harbor gene alterations. Recently, it was reported that gene editing enzyme, activation-induced cytidine deaminase (AID), is expressed in precursor and cancer epithelial cells during carcinogenesis associated with chronic inflammation/infection and that this enzyme induces mutation of tumor-suppressor genes. Thus, AID may have a role in carcinogenesis via oral epithelial dysplasia. In this study, we classified oral mucosal epithelium exhibiting epithelial dysplasia as squamous intraepithelial neoplasia (SIN) grades 1-3, according to the 2005 World Health Organization classification, and used immunohistochemical techniques to examine AID expression in oral mucosal epithelium exhibiting SIN and oral cancer tissues. AID was observed in prickle cells in oral mucosal epithelium with epithelial dysplasia and in oral cancer cells. Additionally, to investigate the mechanism of AID expression and its role in cancer progression, we incubated the oral cancer cell line HSC-2 with inflammatory cytokines. In the HSC-2 cell line, AID expression was enhanced by TNF-α via NF-κB activation and promoted expression of N-cadherin by regulating Snail expression. T...Continue Reading

References

Dec 1, 1990·Diseases of the Colon and Rectum·W E RoedigerB C Radcliffe
Aug 1, 1993·Seminars in Cell Biology·U Kim, K Nishikura
May 1, 1993·Journal of Gastroenterology and Hepatology·A Nomura, G N Stemmermann
Jan 1, 1995·Acta Anatomica·E D Hay
Jul 3, 1999·Nucleic Acids Research·H Y Yi-BrunozziP A Beal
Jul 15, 1999·Biochemical and Biophysical Research Communications·W LiaoL Chan
Nov 5, 2002·The American Journal of Pathology·Erika RosivatzKarl-Friedrich Becker
May 7, 2003·The Journal of Experimental Medicine·Il-mi OkazakiTasuku Honjo
May 22, 2004·Annals of the New York Academy of Sciences·Rachel B HazanKimita Suyama
Jun 23, 2005·Nature Immunology·Tasuku HonjoMasamichi Muramatsu
Nov 3, 2005·Nature Clinical Practice. Oncology·Steven F Moss, Martin J Blaser
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Tadayuki KouTsutomu Chiba
Apr 7, 2007·Nature Medicine·Shigeo Takaishi, Timothy C Wang
Apr 9, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chang Jae KimWon Sang Park
Sep 11, 2008·International Journal of Cancer. Journal International Du Cancer·Toshiyuki MorisawaTsutomu Chiba
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Feb 4, 2011·Annals of Surgical Oncology·Kazuya ShinmuraHaruhiko Sugimura

❮ Previous
Next ❯

Citations

Jul 30, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ignacio Gonzalez SeguraAna M Zarate

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.