Abstract
To determine the role of inflammatory products of phospholipid metabolism in acute otitis media (AOM), we infected 128 chinchillas with Streptococcus pneumoniae and randomly assigned them to one of four equal-sized treatment groups receiving intramuscular ampicillin sodium (control) or intramuscular ampicillin plus receptor blockers of platelet activating factor (WEB 2086, 5 mg/d orally), of leukotriene (MK 571, 0.5 mg/d orally), or of thromboxaneA2 (GR 32191B, 5 mg/d orally). All treatments were begun on day 2 postinoculation and continued for 10 days. On days 3, 6, 9, and 12, 8 animals from each group were sacrificed. Effusions were recovered for biochemical assay, and the right middle ears were prepared for histologic study. Differences among groups in the number of ears with effusion or in effusion volume were not statistically significant. In comparison to the control group, mucosal thickness and the number of ears with histopathologic signs of inflammation were significantly less in the GR and WEB treatment groups, but not the MK group. Also, effusion concentrations of free fatty acids, protease, and hydrolytic enzymes were significantly less in those groups. These results show that the addition of a receptor blocker for ...Continue Reading
References
Jun 1, 1978·The Biochemical Journal·B Dahlmann, H Reinauer
Nov 1, 1979·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J M BernsteinM C Rattazzi
Mar 1, 1976·The Annals of Otology, Rhinology, and Laryngology·S K Juhn, J S Huff
Aug 1, 1992·The Pediatric Infectious Disease Journal·C D BluestoneL M Martin
Jul 1, 1991·The Annals of Otology, Rhinology, and Laryngology·L BrodskyP L Ogra
Jan 1, 1992·Archives of Otolaryngology--head & Neck Surgery·R M RosenfeldB P Pinero
Aug 1, 1991·British Journal of Clinical Pharmacology·M ThomasP Lumley
May 1, 1991·The Annals of Otology, Rhinology, and Laryngology·N NonomuraS K Juhn
Jun 1, 1990·The Annals of Otology, Rhinology & Laryngology. Supplement·T T JungS K Juhn
Jan 1, 1990·Archives of Otolaryngology--head & Neck Surgery·T HaradaG L Adams
Jan 1, 1990·The Pediatric Infectious Disease Journal·G S GiebinkA E Seltz
Jan 1, 1989·Canadian Journal of Physiology and Pharmacology·T R JonesP Masson
May 1, 1989·The Annals of Otology, Rhinology, and Laryngology·I B VarsanoJ E Grossman
Jan 1, 1988·Archives of Otolaryngology--head & Neck Surgery·W F DivenB Vietmeier
May 1, 1988·The Annals of Otology, Rhinology & Laryngology. Supplement·T T Jung
Mar 1, 1986·The Journal of Laryngology and Otology·S AbramovichR Lavelle
Mar 1, 1985·The Annals of Otology, Rhinology, and Laryngology·P BoisvertA F Ryan
Jul 1, 1983·British Medical Bulletin·J R Mitchell
Jul 1, 1983·British Medical Bulletin·B J Whittle, S Moncada
Jan 1, 1984·The Annals of Otology, Rhinology, and Laryngology·T F DeMariaN Okazaki
Mar 1, 1981·The Annals of Otology, Rhinology, and Laryngology·W F DivenC D Bluestone
Jan 1, 1995·Auris, Nasus, Larynx·W F DivenW J Doyle
Mar 1, 1994·The Journal of Pediatrics·R M RosenfeldD M Canafax
Aug 1, 1993·The Annals of Otology, Rhinology, and Laryngology·C K RheeD Weeks
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Citations
Oct 30, 2004·The Laryngoscope·Charles D Bluestone
Jul 3, 2016·International Journal of Pediatric Otorhinolaryngology·Yoshihisa NakamuraShingo Murakami
Oct 20, 2001·The Annals of Otology, Rhinology, and Laryngology·E J JeonT T Jung
Jul 11, 1998·The Annals of Otology, Rhinology, and Laryngology·P A HebdaA Zeevi
Sep 28, 2002·The Laryngoscope·Patricia A HebdaWilliam J Doyle
May 28, 2002·Acta Oto-laryngologica·Patricia A HebdaWilliam J Doyle
Apr 24, 2002·The Annals of Otology, Rhinology & Laryngology. Supplement·Cuneyt M AlperTomonori Takasaka