Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma

Journal of Endocrinological Investigation
M NakashimaS Nagataki

Abstract

The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-4, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance.

References

Jan 17, 1991·Nature·T A Springer, L A Lasky
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Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P JohnsonG Riethmüller
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Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·M NakashimaS Nagataki

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