PMID: 8952617Sep 1, 1996Paper

Expression of adhesion molecules during tooth resorption in feline teeth: a model system for aggressive osteoclastic activity

Journal of Dental Research
Y ShigeyamaM J Somerman

Abstract

Tooth resorption, a common feline dental problem, is often initiated at the cemento-enamel junction and hence is called cat 'neck' lesion. Studies have demonstrated that osteoclasts/odontoclasts are increased and activated at resorption sites, and that areas of resorption are partly repaired by formation of tissues resembling bone, cementum, and possibly dentin. However, the cellular/molecular mechanisms/factors involved in resorption and repair are unknown. In this study of tissues from cats with 'neck' lesions, we used specific antibodies and immunohistochemical analyses to examine adhesion molecules associated with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cell-surface receptor linked with these molecules, alpha v beta 3, for their localization in these lesions. In addition, to determine general cellular activity during repair, we performed in situ hybridization using a type I collagen riboprobe. Results showed OPN localized to resorption fronts and reversal lines, while BSP was localized to reversal lines. However, some osteoclasts and odontoblasts "sat" on mineralized surfaces not associated with OPN. The cell-surface receptor, alpha v beta 3, was localized to surfaces of osteoclasts/odontoc...Continue Reading

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Citations

Dec 5, 2002·The Journal of Small Animal Practice·C Gorrel, A Larsson
Feb 25, 1998·Stem Cells·R S Taichman, S G Emerson
Nov 18, 2008·The Veterinary Journal·Carsten StaszykHubert Simhofer
Jun 28, 2005·The Veterinary Clinics of North America. Small Animal Practice·Alexander M ReiterAyako Okuda
Aug 1, 2002·The Veterinary Clinics of North America. Small Animal Practice·Alexander M Reiter, Krista A Mendoza
Dec 21, 2014·Journal of Feline Medicine and Surgery·Cecilia Gorrel
Nov 26, 2008·Journal of Veterinary Dentistry·N GirardP Hennet
Apr 28, 2004·Journal of Veterinary Dentistry·Colin E HarveyCarolyn Schuster
Mar 16, 2005·Journal of Veterinary Dentistry·Marianne BergerPeter Schawalder
Jul 28, 2020·The Journal of Small Animal Practice·B NiemiecR Jouppi
Feb 7, 2004·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Nabeel TalicA Moneim Zaki
Aug 19, 2004·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Adam LeeThomas Southard
Aug 10, 2021·Frontiers in Dental Medicine·Emily Y ChuVivek Thumbigere-Math

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