Expression of adhesion molecules in rat renal cortex during experimental hydronephrosis

Kidney International
S D RicardoJ R Diamond

Abstract

Unilateral ureteral obstruction (UUO) is associated with an early and steadily increasing infiltration of macrophages into the renal cortical interstitium. As adhesion molecules may play an important role in macrophage recruitment following the mechanical disturbance after UUO, we delineated the time course of intercellular adhesion molecule (ICAM)-1 and vascular adhesion molecule (VCAM)-1 mRNA and protein expression. A significant 6.6- (P < 0.001), 2.6- (P < 0.025), 2.6- (P < 0.01), and 2.0-fold (P < 0.005) increase in ICAM-1 mRNA expression was observed at 12, 24, 48, and 96 hours after obstruction, respectively, in comparison to the contralateral unobstructed kidney (CUK). Despite an apparent relief of obstruction, four weeks following reversal of obstruction mRNA levels of ICAM-1 remained equivalent to the 96-hour obstructed kidney group. No significant difference in VCAM-1 mRNA expression was observed between the obstructed kidneys and CUK specimens. Immunohistochemistry revealed focal labeling of ICAM-1 on the apical and basolateral surface of the renal tubules, peritubular interstitium, and vessels of the renal cortex by 12 hours after UUO. In contrast, only faint staining for ICAM-1 protein was observed in the cortex fr...Continue Reading

References

Aug 1, 1992·Clinical Immunology and Immunopathology·R HarningV J Merluzzi
Aug 1, 1991·Journal of the American Society of Nephrology : JASN·J R Ingelfinger, V J Dzau
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D SeronD O Haskard
Dec 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Klahr
Aug 2, 1990·Nature·T A Springer
Dec 1, 1990·Kidney International·D C BrennanV E Reubin-Kelley
Dec 1, 1989·Kidney International·G A Bishop, B M Hall
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Diamond
Mar 1, 1995·Journal of the American Society of Nephrology : JASN·E EngelmyerJ R Diamond
Jan 1, 1993·Current Opinion in Nephrology and Hypertension·P J Mulrow
May 1, 1994·Kidney International·H R Brady
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Klahr, M L Pukerson
Jun 1, 1993·Blood Reviews·C M Price
Dec 1, 1995·Kidney International·A Dal Canton

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Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Sayuri SuzukiMasatoshi Kitagawa
Dec 17, 2008·Urological Research·Martin ZecherRamón Rodrigo
Apr 4, 2007·Cardiovascular Drugs and Therapy·Jesus Egido, Marta Ruiz-Ortega
Apr 8, 2006·Current Hypertension Reports·Lucia Mazzolai, Daniel Hayoz
Feb 19, 2005·Current Urology Reports·Rosalia Misseri, Kirstan K Meldrum
Aug 28, 2004·The American Journal of Pathology·Xiao Liang ZhangAled Phillips
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
Jan 6, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·A TakedaS Orikasa
Dec 9, 1998·Kidney International·J R DiamondS D Ricardo
Apr 25, 2001·Kidney International·B Rodríguez-IturbeR J Johnson
Apr 23, 2002·Kidney International·Katsuyuki NagatoyaMasatsugu Hori
Mar 13, 2003·Kidney International·Edwina K RiceDavid J Nikolic-Paterson
Aug 5, 2000·Current Opinion in Nephrology and Hypertension·M W TaalH S Mackenzie
Apr 24, 2010·Journal of Inflammation·María T GrandeJosé M López-Novoa
Jan 22, 2011·Journal of Translational Medicine·José M López-NovoaFrancisco J López Hernández
Sep 28, 2013·International Urology and Nephrology·Alvaro C UceroAlberto Ortiz
Dec 4, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Katarzyna Taranta-JanuszJoanna Michaluk-Skutnik
Dec 24, 2005·Kidney International·B Lange-SperandioR L Chevalier
May 18, 2004·The Journal of Surgical Research·Rosalia MisseriKirstan K Meldrum
Jan 18, 2006·The Journal of Surgical Research·Kirstan K MeldrumDaniel R Meldrum
Aug 23, 2001·The Journal of Surgical Research·S I JungC F Freise
Dec 31, 2010·Korean journal of pediatrics·Min Hyun Cho
Dec 3, 2004·Journal of the American Society of Nephrology : JASN·Xiao Liang ZhangAled O Phillips
Jan 14, 1999·The American Journal of Physiology·J J Morrissey, S Klahr
Nov 24, 1999·The American Journal of Physiology·G GuoS Klahr
Apr 18, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bärbel Lange-SperandioRobert L Chevalier
May 6, 2004·American Journal of Physiology. Renal Physiology·Ann Wamsley-DavisDavid Sheikh-Hamad
Apr 8, 1998·The American Journal of Physiology·J J Morrissey, S Klahr
Oct 13, 2006·Current Opinion in Urology·L S YoungJ M Fitzpatrick
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H YamagishiY Utsunomiya

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