Expression of adhesion molecules on endothelial cells stimulated by Chlamydia pneumoniae

Microbial Pathogenesis
S S Kaukoranta-TolvanenK Laitinen

Abstract

Previous studies have shown that C. pneumoniae is able to infect human endothelial cells in vitro. In this report, the ability of C. pneumoniae to induce the expression of E-selectin or endothelial-leukocyte adhesion molecule 1 (ELAM-1), intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) on human umbilical vein endothelial (HUVE) cell surface was investigated. C. pneumoniae was found to cause a moderate upregulation of the adhesion molecules. Maximal expression of E-selectin was noted at 6 h post infection (p.i.) and that of ICAM-1 and VCAM-1 at 20 h p.i. The capability of C. pneumoniae to grow in endothelial cells and to stimulate the expression of adhesion molecules essential for leukocyte-endothelial cell interactions suggests a role for C. pneumoniae as a local pathogenetic factor in vascular inflammatory alterations, including atherogenesis.

Citations

Mar 24, 2004·Nature Reviews. Microbiology·Lee Ann Campbell, Cho-cho Kuo
Apr 13, 2000·Journal of Internal Medicine·P Saikku
Jun 6, 2000·The Journal of Infectious Diseases·J T Grayston
Jun 6, 2000·The Journal of Infectious Diseases·C A Gaydos
Jun 6, 2000·The Journal of Infectious Diseases·M E RosenfeldC Kuo
Jun 6, 2000·The Journal of Infectious Diseases·J T SummersgillJ A Ramirez
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nobuko AsoMasaru Nasu
Nov 14, 2001·Infection and Immunity·S HaranagaY Yamamoto
Jul 16, 2002·Infection and Immunity·M InnocentiM Quiding-Järbrink
Apr 7, 2005·Digestive Diseases·Aydin KöksalAkin Yildiz
Aug 21, 2013·Interdisciplinary Perspectives on Infectious Diseases·Hamidreza Honarmand
Oct 4, 2012·Future Microbiology·Dimitrios ChatzidimitriouNikolaos Malisiovas
Mar 8, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R EzzahiriC A Bruggeman
Sep 14, 2006·European Journal of Clinical Investigation·A E R KartikasariF L J Visseren
Apr 3, 2002·Ophthalmology·Martin WegerEva-Maria Haller-Schober
Oct 29, 2005·Tuberculosis·Rohini QamraBrian Henderson
Nov 1, 2003·Medical Microbiology and Immunology·R LugertU Gross
Jan 17, 2002·Acta Microbiologica Et Immunologica Hungarica·Z KisE Gönczöl
Mar 29, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Andreas E MayFranz-Josef Neumann
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·D VirokE Gonczol
Jun 24, 2009·Circulation·Stephen E EpsteinMary S Burnett
Jan 10, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M HögdahlE Kihlström
Jul 27, 2010·Fundamental & Clinical Pharmacology·Justin F Deniset, Grant N Pierce
Apr 8, 2006·Physiological Reviews·Alain Tedgui, Ziad Mallat
Jul 23, 2013·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Akira Harada, Yoshinori Takashima

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