Expression of alpha 2 adrenoceptors during rat brain development--I. Alpha 2A messenger RNA expression

Neuroscience
U H Winzer-SerhanF M Leslie

Abstract

The distribution of alpha 2A adrenoceptor messenger RNA expression in developing rat brain was characterized using in situ hybridization with 35S-labeled riboprobes. Intense hybridization signal was detected as early as embryonic day 14 in several areas adjacent to the forebrain and hindbrain germinal zones and in central noradrenergic neurons. A marked increase in messenger RNA expression was observed throughout the brain during late prenatal development, consistent with the migration and maturation of neurons in developing brain structures. In embryonic brain, there was a temporal and spatial correspondence in the appearance of alpha 2A messenger RNA expression and binding sites labeled with [3H]idazoxan or p-[125I]iodoclonidine, indicating translation into receptor protein at an early stage of development. Whereas the presynaptic expression remained constant throughout development, there was an early postnatal decline of alpha 2A receptor expression in many brain regions, including the olfactory bulb, cortex, caudate-putamen, hippocampus, thalamus, hypothalamus and medulla. Thereafter, messenger RNA expression increased, establishing an adult-like pattern during the second postnatal week, but remained low in areas such as th...Continue Reading

References

Jan 13, 1978·Brain Research·P Levitt, R Y Moore
Feb 1, 1992·Pharmacology, Biochemistry, and Behavior·J K WamsleyD B Bylund
Jun 21, 1991·Brain Research. Developmental Brain Research·R M SullivanM Leon
Jan 1, 1991·Progress in Brain Research·K C MarshallJ T Williams
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D W ZengK R Lynch
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J W LomasneyR J Lefkowitz
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W ReganB K Kobilka
May 1, 1985·Pharmacology, Biochemistry, and Behavior·D B Bylund
Sep 1, 1987·Journal of Neurophysiology·S NakamuraT Sakaguchi
May 19, 1980·Brain Research·M J MorrisP Meyer
Aug 5, 1983·European Journal of Pharmacology·E J Hartley, P Seeman
Feb 20, 1982·The Journal of Comparative Neurology·M E Blue, J G Parnavelas
Jul 15, 1980·The Journal of Comparative Neurology·M SchlumpfF E Bloom
Jul 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·N LimbergerK Starke
Apr 1, 1995·Neuropharmacology·L Hein, B K Kobilka
Apr 18, 1995·Brain Research. Developmental Brain Research·S Rangel, M Leon
Jan 1, 1994·Brain Research. Molecular Brain Research·M ScheininR T Fremeau
Feb 22, 1993·The Journal of Comparative Neurology·A P NicholasT Hökfelt
Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·A U TrendelenburgK Starke
Sep 25, 1995·The Journal of Comparative Neurology·M S Lidow, P Rakic

❮ Previous
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Citations

Jan 12, 2002·British Journal of Pharmacology·Peregrine B OsborneMacDonald J Christie
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John M BishaiLawrence D Longo
Feb 17, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William MarrsJ David Jentsch
Jul 21, 2012·Journal of Neurophysiology·Sruthi Pandipati, Nathan E Schoppa
Feb 20, 2016·Journal of Child and Adolescent Psychopharmacology·Benjamin T BlackBridgette L Jones
Sep 16, 2019·Journal of Neural Transmission·Mediha TurktanDilek Ozcengiz
Sep 21, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guey-Shin WangAlice Chien Chang
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Bortolozzi, F Artigas
Feb 19, 2013·PloS One·Angela PignatelliOttorino Belluzzi
Feb 18, 1999·Journal of Neurobiology·U H Winzer-Serhan, F M Leslie
Apr 3, 2003·The European Journal of Neuroscience·Denys V VolginLeszek Kubin
Nov 29, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L DesnoyersB M Fendly
Oct 16, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mark J FerrisRosemarie M Booze
Mar 12, 2008·Addiction Biology·Jeffery H PenznerKaren K Szumlinski
Dec 26, 2012·The Journal of Physiology·Nathan C ZimnikRicardo C Araneda
Jan 30, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Carlo PancaroJames E Marchand
Oct 23, 1997·The Journal of Comparative Neurology·U H Winzer-Serhan, F M Leslie
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Jan 29, 2011·Journal of Neurophysiology·Christiane LinsterMatthew Ennis
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Buchholz, S P Duckles
Oct 18, 2020·The Journal of Comparative Neurology·Charles A WilliamsDavid J Perkel
Jun 1, 1997·Trends in Pharmacological Sciences·E MacDonaldM Scheinin
Jul 13, 2002·Pharmacology & Therapeutics·David Weinshenker, Patricia Szot
Mar 8, 2002·Brain Research. Developmental Brain Research·Yi HuangJohn W Regan
Aug 30, 2005·Cellular Signalling·Jin-Sheng HuangGuy C Le Breton

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