Expression of alpha-7 nAChRs on spinal cord-brainstem neurons controlling inspiratory drive to the diaphragm

Respiratory Physiology & Neurobiology
Ozra DehkordiSyed I Zaidi

Abstract

In the present study, we determined whether alpha-7 subunit containing nicotinic acetylcholine receptors (nAChRs) are expressed by neurons within the pre-Botzinger complex (pre-BotC), bulbospinal, and phrenic motor nuclei in the rat. alpha-7 Immunohistochemistry combined with cholera toxin B (CTB), a retrograde tracer was used to detect expression of alpha-7 nAChRs by phrenic motor and bulbospinal neurons. Neurokinin-1 receptor immunoreactivity was used as a marker for pre-BotC neurons. Of the CTB-positive neurons in the phrenic nuclei, 60% exhibited immunoreactivity for alpha-7 nAChRs. Of the bulbospinal neurons in the paramedian reticular nuclei (PMn), gigantocellular nuclei (Gi), raphe nuclei, rostral ventrolateral medulla (RVLM) and nucleus tractus solitarius, 20-50% were found to express alpha-7 nAChR immunoreactivity. Of the peudorabies virus (PRV) labeled bulbospinal neurons in PMn, Gi, raphe and RVLM, 9-12% co-expressed alpha-7 nAChRs. Immunoreactivity for alpha-7 nAChRs was also detected in 57% of the neurokinin-1 receptor containing neurons presumed to reside in pre-BotC. These findings suggest that nicotinic cholinergic regulation of the chest wall pumping muscles may occur at multiple levels of the central nervous s...Continue Reading

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Citations

Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xuesi M ShaoJack L Feldman
Jun 6, 2009·Acta Pharmacologica Sinica·Xuesi M Shao, Jack L Feldman
Aug 13, 2013·Respiratory Physiology & Neurobiology·Jennifer L CareyRomolo J Gaspari
Feb 3, 2007·Respiratory Physiology & Neurobiology·Sébastien ZanellaGérard Hilaire
Sep 30, 2010·The Journal of Comparative Neurology·Amine N IssaCarlos B Mantilla
Apr 9, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ramanujam SriramaGudasalamani Ravikanth
Nov 10, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cherylea J BrowneRita Machaalani
Dec 13, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kurt RasmussenJane B Acri
May 29, 2009·Clinical and Experimental Pharmacology & Physiology·Marlys CamposJaime Eugenín

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