PMID: 8962117Dec 10, 1996Paper

Expression of alpha v and beta 3 integrin chains on murine lymphocytes

Proceedings of the National Academy of Sciences of the United States of America
D J GerberS Tonegawa

Abstract

The vitronectin receptor is a member of the integrin family of adhesion protein receptors and binds a broad spectrum of ligands, including fibronectin and fibrinogen in addition to vitronectin. We have generated four mAbs that recognize the murine alpha v beta 3 vitronectin receptor. Biochemical and expression analyses showed that two of the mAbs are specific for the alpha v chain, and two are specific for the beta 3 chain. The mAbs are effective blocking reagents and inhibited cell adhesion to vitronectin, fibrinogen, and fibronectin. Staining analysis revealed expression of alpha v and beta 3 on certain populations of murine thymocytes, splenocytes, and bone marrow cells. The expression of alpha v and beta 3 appeared to be modulated at specific stages of thymocyte development, suggesting a possible function for the alpha v beta 3 vitronectin receptor in T cell development.

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Citations

Dec 1, 2007·Cancer Metastasis Reviews·Philip Y Wai, Paul C Kuo
Dec 4, 2003·Experimental Cell Research·Michael A Chernousov, David J Carey
Apr 12, 2001·International Journal of Experimental Pathology·A O'Regan, J S Berman
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shuguang BiLinda G Baum
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tony SchountzBrian Hjelle
Oct 27, 2004·The Journal of Surgical Research·Philip Y Wai, Paul C Kuo
Aug 27, 2013·Advanced Functional Materials·Mei-Hsiu LaiHyunjoon Kong
Sep 16, 2008·European Journal of Immunology·Satoshi KasaiToshiyuki Takai
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M R SchmidtR T Woodland
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H GuoP C Kuo
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshihiko OkiToshio Kitamura
Sep 8, 1998·Clinical and Diagnostic Laboratory Immunology·K RiesbeckM Dohlsten

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