Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors

Virology
Tathagata ChoudhuriErle S Robertson

Abstract

Epstein-Barr virus (EBV) is a lymphotrophic herpesvirus infecting most of the world's population. It is associated with a number of human lymphoid and epithelial tumors and lymphoproliferative diseases in immunocompromised patients. A subset of latent EBV antigens is required for immortalization of primary B-lymphocytes. The metastatic suppressor Nm23-H1 which is downregulated in human invasive breast carcinoma reduces the migration and metastatic activity of breast carcinoma cells when expressed from a heterologous promoter. Interestingly, the EBV nuclear antigen 3C (EBNA3C) reverses these activities of Nm23-H1. The alpha V integrins recognize a variety of ligands for signaling and are involved in cell migration and proliferation and also serve as major receptors for extracellular-matrix-mediated cell adhesion and migration. The goal of this study was to determine if Nm23-H1 and EBNA3C can modulate alpha V integrin expression and downstream activities. The results of our studies indicate that Nm23-H1 downregulates alpha V intregrin expression in a dose responsive manner. In contrast, EBNA3C can upregulate alpha V integrin expression. Furthermore, the study showed that the association of the Sp1 and GATA transcription factors w...Continue Reading

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Citations

Oct 15, 2008·Expert Opinion on Therapeutic Targets·BuHyun YounJoon Kim
Aug 19, 2011·FEBS Letters·Abhik Saha, Erle S Robertson
May 13, 2008·International Journal of Cancer. Journal International Du Cancer·Masanao MurakamiErle S Robertson
Jun 30, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Natascia MarinoPatricia S Steeg
Oct 31, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shalu SharmaShantanu Chowdhury
Oct 24, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gemma S PutsDavid M Kaetzel
Oct 17, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Saurabh Pandey, Erle S Robertson
May 5, 2009·Molecular and Cellular Biochemistry·Masanao MurakamiErle S Robertson
Apr 21, 2009·Molecular and Cellular Biochemistry·Hag Dong KimJoon Kim

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