PMID: 9419010Jan 7, 1998Paper

Expression of alpha vbeta3 and alpha vbeta8 integrins during oligodendrocyte precursor differentiation in the presence and absence of axons

Glia
R MilnerCharles Ffrench-Constant

Abstract

We have shown previously that switching of the alpha v-associated beta1 and beta5 integrin subunits during differentiation of myelin-forming oligodendrocytes may regulate important aspects of cell behaviour such as migration (Milner et al., 1996: J Neurosci 16:7240-7252). In this study we have examined the developmental regulation of other alpha v-associated beta subunits in oligodendroglial cell cultures and also the control of their expression by neurons, using xenocultures to distinguish glial and neuronal integrins. We have found that oligodendroglia express alpha vbeta8 in addition to the previously-described alpha vbeta1, alpha vbeta3, and alpha vbeta5. Beta8 and beta3 together comprise the 80kD band seen in alpha v immunoprecipitations that represents the most abundant alpha v-associated beta subunit and show reciprocal patterns of expression during development. Alpha vbeta8 is expressed at high levels on oligodendrocyte precursors and differentiated oligodendrocytes but diminishes during the intermediate stages of differentiation. Alpha vbeta3, in contrast, shows an opposite pattern of expression, with the highest levels seen at the intermediate stages of differentiation and little expression on either oligodendrocyte p...Continue Reading

Citations

Oct 23, 2009·Acta Neuropathologica·Monika Bradl, Hans Lassmann
Apr 17, 2009·Journal of Neural Transmission·Brinda S DesaiBill Hendey
Aug 23, 2005·Brain Research. Brain Research Reviews·Fernando de Castro, Ana Bribián
Oct 16, 2004·Molecular and Cellular Neurosciences·Michael A FoxBabette Fuss
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John M ProctorLouis F Reichardt
Dec 17, 2009·Archives of Neurology·Brent R WrightMoses Rodriguez
Jul 13, 2011·Journal of Neural Transmission·Brinda Desai BradaricBill Hendey
Nov 11, 1999·Current Biology : CB·E E FrostC ffrench-Constant

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.