PMID: 7515025Jan 1, 1994Paper

Expression of alternatively spliced forms of the CD44 extracellular-matrix receptor on human lung carcinomas

International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement
D G JacksonR A Stahel

Abstract

Expression of isoforms of the CD44 hyaluronan receptor/lymph-node endothelial receptor by human tumour cells is thought to play a role in tumour growth and metastasis. These isoforms which vary in the length of the extracellular domain are generated by differential RNA splicing that involves the 10 alternative exons (v1 to v10) encoding the membrane proximal region of the molecule. Several tumours have been shown to over-express CD44 containing the v6 exon, and this, together with other evidence, has led to the suggestion that v6 may play a causative role in tumour metastasis. In this report we have compared the expression of CD44 isoforms between different lung tumour lines, including SCLC, squamous-cell carcinoma, adenocarcinoma and mesothelioma, using both RT-PCR and fluorescent antibody staining with a panel of CD44 exon-specific monoclonal antibodies (MAbs). Our results show large differences in vCD44 expression between individual tumour lines. Little or no vCD44 containing the metastasis-associated v6 exon was detected in most tumours, including the highly metastatic SCLC lines. Indeed, the SCLC lines and some squamous-cell carcinomas contained only very low levels of either vCD44 or CD44H, indicating that CD44 expression...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Aug 1, 1992·The Journal of Experimental Medicine·M S SyI Stamenkovic
Feb 1, 1992·The Journal of Cell Biology·S Jalkanen, M Jalkanen
Oct 1, 1991·The Journal of Experimental Medicine·M S SyI Stamenkovic
May 1, 1991·The Journal of Clinical Investigation·S JalkanenP Klemi
Jan 1, 1986·Immunogenetics·C M IsackeI S Trowbridge
Aug 28, 1993·Lancet·S B FoxJ Fawcett

❮ Previous
Next ❯

Citations

Dec 1, 1995·Journal of Neuro-oncology·D TarinK Yoshida
Mar 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A WimmelM Schuermann
Oct 8, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N TakigawaN Fujimoto
Jun 1, 1996·Clinical Molecular Pathology·S O SuzukiJ Tateishi
Jul 30, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P Heldin
Sep 26, 2001·Cancer·A WimmelM Schuermann
Jun 30, 1998·International Journal of Cancer. Journal International Du Cancer·R T PirinenV M Kosma
Sep 19, 1998·Molecular and Cellular Biology·M V BellG R Screaton
Jul 4, 1998·Human Pathology·D CoppolaH S Cooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.