PMID: 15374130Jan 1, 1997Paper

Expression of Alzheimer's amyloid precursor protein in human lymphocyte

Archives of Gerontology and Geriatrics
Y H SuhK W Lee

Abstract

Beta-amyloid precursor protein (betaAPP) has been shown to be involved in cell growth regulation. In spleen, the majority of cells showing betaAPP like immunoreactivity was found in the T cell-dependent zone. In Northern blot, the expression of betaAPP was increased to reach the peak at 72 h after the treatment of phytohemagglutinin (PHA). But, in cytofluorometry, almost all CD4(+) T helper/inducer cells and the majority of CD(8+) T suppressor/cytotoxic cells show betaAPP immunoreactivity which remained constant during the stimulation with PHA. These results suggest that betaAPP is a surface molecule of T lymphocyte and the turnover or release of APP might be increased with the treatment of T cell mitogen.

References

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Citations

Nov 17, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antoinette R BaileyJun Tan

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