Expression of Androgen Receptor and Cancer Stem Cell Markers (CD44+ /CD24- and ALDH1+ ): Prognostic Implications in Invasive Breast Cancer

Translational Oncology
Nazia RiazEl-Nasir Lalani

Abstract

Androgen receptor (AR) has emerged as a significant prognostic marker in early breast cancer (BCa). Association of AR with cancer stem cell (CSC) markers in BCa is unknown. Aim of the present study was to evaluate the immunohistochemical expression of AR, CD44, CD24 and ALDH1 in a cohort of Pakistani patients diagnosed with invasive BCa and to correlate the expression with 5- year disease free survival. We evaluated immunohistochemical expression AR, CD44, CD24 and ALDH1 in formalin fixed paraffin embedded archival blocks of 166 cases of primary invasive BCa (stage I-III) and correlated the expression with clinicopathological variables and outcome using univariable and multivariable analysis. Survival data was computed by Kaplan Meier curves. Expression of AR was observed in 62.7% tumors whereas CD44, CD24 and ALDH1 were expressed in 61.4%, 44% and 30.1% tumors, respectively. AR expression was significantly associated with T1-T2 tumors, lower grade, estrogen and progesterone receptor expression (P < .05) and remained an independent prognostic indicator in multivariable analysis (adjusted HR 0.33, 95% CI 0.13-0.81; P = .016). Significant association was observed between concordant expression of AR and CD24 (P = .001) with a favo...Continue Reading

Citations

Mar 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Stella K Vasiliou, Eleftherios P Diamandis
Aug 17, 2018·Cells·Anida Hasanovic, Isabelle Mus-Veteau
Oct 17, 2019·World Journal of Stem Cells·Pia GiovannelliGabriella Castoria
May 4, 2021·Colloids and Surfaces. B, Biointerfaces·Suparna Mercy BasuJyotsnendu Giri
Mar 11, 2021·Cancer Research·Joseph L SottnikDan Theodorescu
Jul 10, 2021·Molecular and Cellular Endocrinology·Yurong Zheng, Antoine E Karnoub

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