PMID: 22568330May 10, 2012Paper

Expression of androgen receptor in genital tissue of patients with congenital hypospadias and simple chordee

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Yu AnMingxing Qiu

Abstract

To investigate the localization and expression characteristics of androgen receptor (AR) in genital tissue of patients with congenital hypospadias and simple chordee. Between August 2005 and January 2007, dorsal prepuce, ventral perimeatal skin, and urethral plate were harvested from 25 patients with congenital hypospadias (aged from 1 year and 11 months to 19 years with an average of 3 years and 7 months) and 4 patients with simple chordee (aged from 3 years and 6 months to 16 years with an average of 7 years and 1 month). Prepuce by circumcision from 18 patients was used as control. The expression intensity and distribution of AR were assessed with immunohistochemistry. AR was expressed in prepuce tissues from congentital hypospadias, simple chordee, and control. The AR positive cell rates were 62.94% +/- 5.40% and 62.87% +/- 5.33% in dorsal and ventral prepuce of control patients respectively, and were 59.00% +/- 3.75%, 58.46% +/- 4.14%, and 52.30% +/- 3.53% in dorsal prepuce, ventral perimeatal skin, and urethral plate of patients with congenital hypospadias respectively. AR positive cell rate was significantly lower in patients with congenital hypospadias than in control patients (P < 0.05), and in urethral plate than in d...Continue Reading

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