PMID: 9533962May 12, 1998Paper

Expression of androgen receptor mRNA during mouse embryogenesis

Mechanisms of Development
A CrocollM Blum

Abstract

Androgen receptor (AR) is a member of the nuclear receptor superfamily which acts as a ligand-dependent transcription factor (Beato, M., Herrlich, P., Schütz, 1989. Steroid hormone receptors: many actors in search of a plot. Cell 83, 851-857). It plays a pivotal role in sexual development and reproduction (Wilson, J.D., Griffin, J.E., George, F.W., Leshin, M., 1981. The role of gonadal steroids in sexual differentiation. Rec. Prog. Horm. Res. 37, 1-39; Jost, A., 1990. Hormonal control of the masculinization of the body. In: Baulieu, E.E., Kelly, D.A., (Eds.), Hormones, from Molecules to Disease. Chapman and Hall, New York and London, pp. 439-442.). Mutations in the AR sequence cause a number of physiological disorders, such as partial and complete androgen insensitivity syndromes, that lead to abnormal sexual development (Patterson, M.N., McPhaul, M.J., Hughes, I.A., 1994. Androgen insensitivity syndrome. Ballière's Clin. Endocrinol. Metab. 8, 379-404.). There are indications that AR may also have other functions. For example, structural alterations of the AR sequence have been implicated in prostate cancer (Visakorpi, T., Huytinen, E., Koivisto, P., Tanner, M., Keinänen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., K...Continue Reading

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Citations

Jun 14, 2005·Fertility and Sterility·Jarmo JääskeläinenSeppo Heinonen
Dec 15, 2000·Progress in Neurobiology·M F Mehler, S Gokhan
Mar 28, 2008·BMC Physiology·Jonathan TootDaniel Ely
Apr 1, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Alexandra Kollara, Theodore J Brown
Jun 19, 2012·Nature Reviews. Genetics·Irene Gallego RomeroYoav Gilad
May 7, 2015·International Journal of Endocrinology·Verónica Palmira FilippaFabian Heber Mohamed
Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Christine E LarkinsMartin J Cohn
Mar 18, 2016·International Journal of Oncology·Agata Poniewierska-BaranMariusz Z Ratajczak
Sep 24, 2015·Development·Lucía F Franchini, Katherine S Pollard
Oct 27, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gerard A TarulliMarilyn B Renfree

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