Expression of Angiogenic Factors in Psoriasis Vulgaris

Journal of Clinical and Diagnostic Research : JCDR
Lakshna SankarPriyanka Pradeep

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, abnormal differentiation and inflammatory infiltration in the dermis. The dermal microvascular expansion associated with abnormal orientation and dilatation of capillaries in the biopsies of the psoriatic skin suggest that the disease is dependent on angiogenesis. To analyze and compare the immunohistochemical expression of angiogenic factors - Vascular Endothelial Growth Factor (VEGF), von Willebrand Factor (vWF) and CD 34 in skin biopsies of psoriasis cases with control skin samples; and to correlate the expression of angiogenic factors with Psoriasis Area and Severity Clinical Index (PASI SCORE). This was a prospective case control study conducted over a period of 15 months. Thirty-two psoriasis cases and thirty control skin samples were included in the study. Skin biopsy specimen was taken from clinically diagnosed psoriasis cases who did not receive any treatment. The diagnosis of psoriasis vulgaris was confirmed after microscopic examination. Immunohistochemical expression for VEGF, vWF and CD 34 was studied. VEGF expression in epidermis was significantly higher in cases when compared to control skin (p <0.01). CD 34 expression...Continue Reading

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Journal of the European Academy of Dermatology and Venereology : JEADV
A NofalA Abdalmoati
Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
Wojciech BaranGrazyna Szybejko-Machaj
Indian Journal of Pathology & Microbiology
Maha Mohamed Amin, Zeinab Abdel Azim
Archives of Iranian Medicine
Mehdi Taheri SarvtinZohreh HajHeydari
© 2022 Meta ULC. All rights reserved