Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.

Medical Hypotheses
Kinan Drak Alsibai

Abstract

Recently, a mini-review was published in the Medical Hypotheses journal by Usul Afsar entitled 2019-nCoV-SARS-CoV-2 (COVID-19) infection: Cruciality of Furin and relevance with cancer. Previous studies have pointed out that disruption of the proteolytic cleavage of proteins can promote infectious and non-infectious diseases. The last few weeks have been marked by an important revelation concerning the pathophysiology of SARS-CoV-2. This new coronavirus disease (COVID-19) is a highly contagious and transmissible acute respiratory infectious disorder. SARS-CoV-2 is composed of RNA-dependent RNA polymerase and structural proteins including Spike protein (S protein). Interestingly, the FURIN, one of the proproteins of the convertase family, plays a crucial role in the maturation of viral glycoproteins. In addition, many viruses including coronaviruses, exploit FURIN for the activation of their glycoproteins. Recent data indicate that SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2. Subsequently, the S protein is cleaved by transmembrane protease serine 2 with the help of FURIN which facilitates the entry of the virus into the cell after binding. Furthermore, it seems that FURIN is implicated in the patho...Continue Reading

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Citations

Jul 22, 2020·Journal of Medical Virology·Laura Torre-FuentesJordi A Matías-Guiu
Aug 10, 2020·Journal of Cardiovascular Pharmacology·Antonis S ManolisHelen Melita
Oct 20, 2020·Frontiers in Cellular and Infection Microbiology·Ziqin DengTing Wang
Mar 6, 2021·Biochemical Society Transactions·Devanshi Mishra, Chinmoy Sankar Dey
Mar 2, 2021·Frontiers in Medicine·Thomas GraierPeter Wolf
Apr 16, 2021·Pathology, Research and Practice·Abhishek MohantySudhir Rawal
Jun 13, 2021·Signal Transduction and Targeted Therapy·Qianqian ZhangFei Yu
Jun 15, 2021·Frontiers in Cardiovascular Medicine·Randa M Breikaa, Brenda Lilly

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Methods Mentioned

BETA
GTPase
GTPases
scRNA-seq
RNA-seq

Software Mentioned

Ensembl
Gene Set Enrichment Analysis ( GSEA )
GSEA

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