Expression of annexin II in gastric carcinoma and its role in gastric cancer metastasis

World Journal of Gastroenterology : WJG
Feng HanMing-Liang Lu

Abstract

To investigate the expression of annexin II in gastric carcinoma and its role in the metastasis of gastric cancer. The expression of annexin II in 51 cases of gastric carcinoma and 24 cases of adjacent tissues was detected by immunohistochemistry. The relationship between annexin II and clinical features of gastric cancer was analyzed. Annexin II specific siRNA was used to inhibit the expression of annexin II in gastric cancer HGC-27 cells, and the effects of annexin II on the migration and secretion of matrix metalloproteinases (MMPs) were observed. The positive rate of annexin II protein was 82.4% in gastric cancer tissues and 37.5% in adjacent tissues. There was significant difference between the two groups (P < 0.01); and the positive expression of annexin II was not related to the sex and age of the patients (P > 0.05). The expression of annexin II protein was correlated with tumor size, histological differentiation, TNM stage, Lymph node metastasis and other clinical features were significantly correlated, the difference was statistically significant (P < 0.05). Inhibition of annexin II expression, gastric cancer HGC-27 cells migration and secretion of MMPs were significantly decreased, the difference was statistically si...Continue Reading

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Citations

Jun 2, 2020·World Journal of Gastroenterology : WJG·Li-Wei QiuHai-Jian Zhang
Apr 19, 2020·Computational Biology and Chemistry·Yong-Ying QinXiao-Zhun Tang
Feb 29, 2020·Fertility and Sterility·Hannah M NazriChristian M Becker

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Methods Mentioned

BETA
PCR
light microscopy
electrophoresis

Software Mentioned

Option Monitor
Image J
SPSS

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