PMID: 9527111Apr 4, 1998Paper

Expression of annexin II in human middle ear cholesteatoma

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
T T KimC C Huang

Abstract

Annexin II has previously been discovered to have involvements in DNA replication and metabolism, bone resorption, and osteoclast formation. In our work, Western blotting and immunohistostaining studies revealed the presence of annexin II in human cholesteatoma tissue. With monoclonal mouse antiannexin II antibody, a 36,000 dalton protein (annexin II) was identified in the cholesteatoma protein extract. Immunoalkaline-phosphatase staining selectively localized annexin II to the keratinocytes in the basal and spinous layers of the cholesteatoma tissue. In normal human skin, annexin II is expressed mainly in the cytoplasmic membrane of its keratinocytes in the basal layer without significant staining in its nucleus. However, annexin II is expressed in both the cytoplasmic membrane and the nucleus of the keratinocytes in basal and spinous layers of human cholesteatomas. Our findings indicate a possible physiologic role of annexin II in keratinocyte cell hyperproliferation during development of human cholesteatoma.

References

Mar 26, 1991·Biochimica Et Biophysica Acta·M Greenwood, A Tsang
Jul 1, 1988·American Journal of Otolaryngology·C C HuangZ X Yi
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y S Cheng, L B Chen
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MasakiK Sogawa

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Citations

Sep 5, 2002·Journal of Cellular Biochemistry·Feridoun Karimi-BusheriAziz Ghahary
Jan 12, 2012·The Journal of Biological Chemistry·Byung-Min ChungPierre A Coulombe
Jan 24, 2007·Human Pathology·Sajjad P SyedJohn J Brooks
Oct 17, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Hiroki KoizumiMotonobu Nakamura
Oct 15, 2013·The Laryngoscope·Khac-Hung NguyenYoshiaki Doi
Sep 2, 2004·Journal of Cell Science·Katharina UhlenbrockMohammad Reza Ahmadian

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