Expression of apoptosis-related proteins in mammary gland of goat

Small Ruminant Research : the Journal of the International Goat Association
P WareskiT Ploszaj

Abstract

The expression of apoptosis-related proteins: TGF-beta1 (auto/paracrine inducer) and its receptor (TGF-betaRIII), Bax (promoter), Bcl-2 (inhibitor) and CPP-32 (executor of apoptosis) as well as the apoptotic cell number in mammary glands of 11 Polish White Improved goats in the course of the lactation cycle (peak of lactation: days 40-70, late lactation: days 208-256, drying off: days 267-340) was investigated. The immunohistochemical study demonstrated a significant increase in TGF-beta1 and TGF-betaRIII expression in the lobuloalveolar tissue from the early lactation to the dry period. Our recent study on HC11 mouse mammary epithelial cells [Cell. Mol. Biol. 46 (2000) 175] has revealed an inhibitory effect of prolactin on TGF-beta1 transcription, which may explain the low TGF-beta1 synthesis during lactogenesis and galactopoiesis and the increase in TGF-beta1 and TGF-betaIIIR expression in late lactation and dry period. Bax expression was the lowest in the peak of lactation, significantly increased in late lactation and remained elevated during drying off. Bcl-2 content was lower than Bax in all examined periods, but it increased significantly at the end of lactation, which suggests the survival of cells with the highest resi...Continue Reading

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Citations

Apr 28, 2009·Journal of Mammary Gland Biology and Neoplasia·Kathleen C Flanders, Lalage M Wakefield
May 3, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·O KolekT Motyl
May 14, 2008·The Journal of Dairy Research·Bibliana E DallardLuis F Calvinho
Dec 2, 2010·The Journal of Dairy Research·Bibiana E DallardLuis F Calvinho
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·H Ben ChedlyM Boutinaud
Nov 24, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Małgorzata Gajewska, Tomasz Motyl
Mar 1, 2012·Asian-Australasian Journal of Animal Sciences·He-Shuang DiYuan-Yuan Yang
Jan 8, 2017·Journal of Cellular Physiology·Gagandeep Singh-MallahKuljeet Singh
Nov 26, 2016·BMC Veterinary Research·Alessandra CrisàBianca Moioli

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