Expression of apoptotic regulators and their significance in cervical cancer

Cancer Letters
T K H ChungY F Wong

Abstract

Insufficient apoptosis is implicated in many human cancers, including cervical carcinoma. The objectives of this study were to explore changes of apoptosis-regulating gene expression and their clinical significance in cervical cancer. The expression of apoptosis-regulating genes, including five Bcl-2 family and two caspase family members, was evaluated in 43 cervical invasive squamous cell carcinomas, using immunohistochemistry. Specimens in which >or=10% of the neoplastic cells showed cytosolic immunoreactivity were considered to be immunopositive. Results were correlated with clinico-pathologic characteristics of the subjects. All seven apoptotic regulators examined were positive in a proportion of the tumors. The percentage of cases expressing Bax was higher in the patients without evidence of disease after treatment than in the patients alive with disease or who died of disease (P<0.05). A significant difference in disease-free survival was detected between Bax-positive and -negative groups (P<0.05), and in overall survival between Mcl-1-positive and -negative groups (P<0.05). Significant association between the seven markers tested was only found for caspase 3 and Bak immunoreactivity in cervical carcinoma (P<0.05). The re...Continue Reading

References

Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KozopasR W Craig
Nov 14, 2000·The American Journal of Pathology·J C Reed

❮ Previous
Next ❯

Citations

Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·Xueli FanJason J Chen
May 21, 2005·Nature Reviews. Cancer·Martin E Gleave, Brett P Monia
May 27, 2005·Journal of Clinical Pathology·G Van de PutteG B Kristensen
Jan 4, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·A SinghN Singh
May 11, 2011·European Journal of Histochemistry : EJH·Z ProtrkaJ Djuric
Nov 18, 2005·Journal of Hepatology·Wolfgang SieghartVolker Wacheck
Aug 15, 2015·Apoptosis : an International Journal on Programmed Cell Death·Ana Teresa G FernandesMaria da Gloria Bonecini-Almeida
Apr 15, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Markus BrunnerBoban M Erovic
Dec 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongjie YuanXia Ma
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tateki YoshinoMikio Igawa
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Phyllis A SvingenScott H Kaufmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.