Expression of AQP3 and AQP5 as a prognostic marker in triple-negative breast cancer

Oncology Letters
Zhengcai ZhuHaixin Qian

Abstract

Triple-negative breast cancer (TNBC) is a common type of breast malignancy with high a propensity for metastasis and locoregional recurrence. The aim of the present study was to investigate the expression of aquaporin (AQP) 3 and AQP5, analyze their association with clinicopathological parameters and explore their clinical significance in tissue samples from patients with TNBC. Immunohistochemistry was performed to detect the expression patterns of AQP3 and AQP5 in 96 patients with TNBC who underwent surgery between 2007 and 2012. AQP3 and AQP5 were expressed primarily in the membrane and cytoplasm of tumor cells within TNBC tissues. AQP3 and AQP5 expression was notably stronger in carcinoma tissue compared with adjacent normal tissue. Overexpression of AQP3 and AQP5 was significantly associated with tumor size, lymph node status and local relapse/distant metastasis. In addition, aberrant overexpression of AQP5 was observed more frequently in TNBC tissues with higher Ki-67 expression than in those with lower Ki-67 expression. In univariate analysis, patients with TNBC with high AQP3 and AQP5 expression demonstrated poorer 5-year disease-free survival and overall survival compared with patients with low AQP3 and AQP5 expression....Continue Reading

References

Jan 29, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lizong ShenWenxi Wu
Oct 29, 2010·Journal of Hematology & Oncology·Rafael Santana-Davila, Edith A Perez
May 27, 2011·Archives of Gynecology and Obstetrics·Jianhua YangXuejun Chen
Jan 18, 2012·Annual Review of Medicine·A S Verkman
May 12, 2012·International Journal of Oncology·Shunsuke IshimotoYoshinori Kamisaki
Sep 26, 2013·Biochimica Et Biophysica Acta·Domenico RibattiBeatrice Nico
Oct 12, 2013·Annals of Surgical Oncology·Soo Jung LeeTae-Hwan Kwon
Nov 6, 2013·Biochimica Et Biophysica Acta·Kenichi IshibashiYoshiyuki Morishita
Nov 14, 2013·BioMed Research International·Xiaodong GuoYuejuan Gao
Dec 18, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristina Esteva-FontA S Verkman
Feb 18, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Markus C KowarikJeffrey L Bennett
Mar 15, 2014·Nature Reviews. Drug Discovery·Alan S VerkmanMarios C Papadopoulos
Jun 3, 2014·Journal of Experimental & Clinical Cancer Research : CR·Jia ChenLi-Zong Shen
Sep 11, 2014·Biochimica Et Biophysica Acta·Marios C Papadopoulos, Samira Saadoun
Apr 18, 2015·Journal of Translational Medicine·Jian WangHongzhi Sun
Sep 14, 2016·Expert Opinion on Therapeutic Patents·Graça Soveral, Angela Casini
Nov 7, 2016·Current Problems in Cancer·Ayca Gucalp, Tiffany A Traina
Dec 31, 2016·International Journal of Molecular Sciences·Aristotelis S FilippidisHarold L Rekate
Mar 5, 2017·Advances in Experimental Medicine and Biology·Yingjie LiBaoxue Yang
May 5, 2017·Journal of Surgical Oncology·Inês DireitoGraça Soveral
Jul 19, 2017·International Journal of Molecular Sciences·Nobutomo IkarashiKiyoshi Sugiyama

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Citations

Sep 26, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhiyuan MaTaolang Li
Jan 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eui-Jung ParkTae-Hwan Kwon
Dec 18, 2018·Oncotarget·Salah DajaniNeelam Sharma-Walia
Dec 14, 2019·Anti-cancer Agents in Medicinal Chemistry·Zhiqin LiuDu-Qiang Luo
Mar 22, 2019·International Journal of Molecular Sciences·Cecilia PrataDiana Fiorentini
Feb 25, 2021·American Journal of Physiology. Cell Physiology·Sarannya EdamanaLene N Nejsum
May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lidija Milković, Ana Čipak Gašparović

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