Sep 11, 2010

Expression of aquaporin-1 in nasopharyngeal cancer tissues

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale
Qi Li, Bao Zhang

Abstract

To investigate the expression of aquaporin-1 (AQP1) in nasopharyngeal tumour and nontumour tissues. Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative polymerase chain reaction (RT-PCR) to detect the expression level of AQP1 in tissues. Immunohistochemistry data suggested that AQP1 was expressed in both nasopharyngeal tumour and normal tissues, but tumour tissues were stained a lot stronger than nontumour tissues. RT-PCR analysis further confirmed the overexpression of AQP1 in tumour tissues; migrated tumour tissue had even higher expression. The expression level of aquaporin-1 in nasopharyngeal cancer tissue could be involved in tumour migration.

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Mentioned in this Paper

Cancer of Nasopharynx
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms
Gene Expression Regulation, Neoplastic
Immunohistochemistry
Biopsy of Nasopharynx
Nasopharynx
Tumor Tissue Sample
Neoplasms
Tumor Lysis Syndrome

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