Abstract
Aquaporins (AQPs) constitute a family of channel proteins implicated in transmembrane water transport. Thirteen different AQPs (AQP0-12) have been described but their precise biologic function still remains unclear. AQPs 1, 3, 4, 8, and 9 expression has been described in human chorion, amnion and placenta; however, AQP4 is the only that has been identified in the first trimester of human pregnancy. To assess multiplicity of AQPs expression from 10th to 14th week gestation. Chorionic villi samples (CVS) collected in pregnant women for prenatal diagnosis were analysed by real time-PCR to assess cDNA expression of AQPs 1, 2, 3, 4, 5, 6, 7, 8, 9, and 11, and compared with AQPs expression in placentas from normal term pregnancies. 26 CVS corresponding to 26 pregnant women (age: 32.7±4.5 years; gestational age: 12.4±0.9 weeks) and 10 placental samples corresponding to normal term pregnancies were analysed. In CVS karyotype was normal in 16 cases, trisomy in 6 cases, mosaicism in 1 and unknown in 1. We found high mRNA expression for AQPs 1, 3, 9 and 11, low for AQPs 4, 5, and 8, and non-detectable for AQPs 2, 6, and 7 in chorionic villi. This is the first study systematically assessing the expression of a multiplicity of AQPs in chori...Continue Reading
References
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G Zaccai
Apr 6, 2005·Biochemical and Biophysical Research Communications·Tomohiro ItohKenichi Ishibashi
Apr 9, 2005·Pediatric Research·Marina ZeleninaAnita Aperia
Aug 19, 2005·Molecular and Cellular Biology·Yoshiyuki MorishitaKenichi Ishibashi
Apr 4, 2006·Biochimica Et Biophysica Acta·Kenichi Ishibashi
Jul 28, 2006·Placenta·M H BeallM G Ross
Dec 13, 2006·Quarterly Reviews of Biophysics·Tamir Gonen, Thomas Walz
Dec 21, 2006·Biochimica Et Biophysica Acta·Kaya YakataYoshinori Fujiyoshi
Jan 27, 2007·Placenta·M H BeallM G Ross
Feb 17, 2007·Placenta·M H BeallM G Ross
Aug 30, 2008·Journal of Clinical Pathology·B Huppertz
Dec 17, 2008·Clinical and Experimental Nephrology·Kenichi IshibashiShintaro Kondo
May 20, 2009·The Journal of Physiology·Christina M Scifres, D Michael Nelson
Jun 24, 2009·Placenta·X Q ZhuY C Hu
Feb 17, 2010·European Journal of Oral Sciences·Helga S LarsenHilde Kanli Galtung
Mar 12, 2010·Reproductive Sciences·Gabriela I MarinoAlicia E Damiano
Dec 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenichi IshibashiYoshiyuki Morishita
Jan 7, 2011·Placenta·A E Damiano
Jan 22, 2011·Journal of Structural Biology·Kaya YakataYoshinori Fujiyoshi
Apr 20, 2011·Cell Cycle·Amaia RodríguezGema Frühbeck
Citations
Dec 2, 2017·International Journal of Molecular Sciences·Eszter DuczaRóbert Gáspár
Feb 8, 2014·Neonatology·Jeroen J van VonderenArjan B te Pas
May 16, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vanessa de OliveiraAndy V Babwah
Sep 22, 2019·Journal of Cellular Physiology·Julieta ReppettiAlicia E Damiano
Oct 19, 2019·International Journal of Molecular Sciences·Mariusz T SkowronskiAgnieszka Skowronska
Mar 19, 2016·Physiological Research·A SkowronskaM T Skowronski
Nov 15, 2018·Frontiers in Physiology·Natalia SzpilbargAlicia E Damiano
Dec 5, 2020·Cells·Paweł KordowitzkiMariusz T Skowronski
Mar 31, 2021·Reproductive Biology and Endocrinology : RB&E·Yingqi NongFenghua Liu