PMID: 18202758Jan 19, 2008Paper

Expression of arginase II in prostate cancer.

International Journal of Oncology
Shannon M MumenthalerWayne W Grody

Abstract

Previous reports have shown elevated arginase activity in prostate cancer patients. This study was designed to compare expression levels of arginase II (AII) in various human prostate cancer cell lines and tissues. Expression levels of AII and other enzymes involved in arginine metabolism were examined in androgen-dependent (LNCaP, LAPC-4) and androgen-independent (PC3, DU145, CL-1, CL-2) prostate cancer cell lines by real-time RT-PCR and Western blot analysis. Further expression analysis of AII was accomplished by immunohistochemical staining of a tissue microarray comprised of 246 primary prostatectomy specimens. In addition, polyamine levels were measured within the prostate cancer cell lines by HPLC. Total polyamines were significantly lower in the androgen-dependent cell lines compared to the androgen-independent cell lines. AII expression was found to be most prominent in the androgen-dependent cell lines and least prominent in the androgen-independent cell lines. Additionally, we found expression of ornithine aminotransferase (OAT), an enzyme also responsible for ornithine production, to be inversely correlated with AII expression. The tissue microarray data revealed that the highest AII expression was seen in BPH, follo...Continue Reading

Citations

Oct 16, 2010·Cellular and Molecular Life Sciences : CMLS·Vera BarraBernhard Brüne
Nov 9, 2010·The Journal of Sexual Medicine·Haroldo A ToqueR William Caldwell
Sep 22, 2009·British Journal of Pharmacology·Markus Munder
Jul 30, 2008·The Prostate·Shannon M MumenthalerWayne W Grody
Jul 9, 2013·Progress in Retinal and Eye Research·S Priya NarayananRuth B Caldwell

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