Expression of B7-2 (CD86) molecules by Reed-Sternberg cells of Hodgkin's disease

Leukemia
S W van GoolJ L Ceuppens

Abstract

Ligation of CD28 on T cells with its natural ligands B7-1 (CD80) or B7-2 (CD86) provides a major costimulatory signal for T cells and is of potential importance for tumor rejection. We previously reported a strong expression of B7-1 on Reed-Sternberg cells and anaplastic large cell lymphoma cells. We report here our findings on B7-2 expression by malignant lymphomas (n = 70). B7-2 was present on the neoplastic cells of anaplastic large cell lymphoma in two of three cases studied, and on a subpopulation of the malignant cells in one out of four cases of follicular lymphoma. B7-2 was not expressed by the neoplastic cells of the other non-Hodgkin's lymphomas (n = 32), including T cell-rich B cell lymphoma. In contrast, Reed-Sternberg cells in lymph nodes affected by Hodgkin's disease are strongly positive for B7-2 (n = 31). Evidence for a functional correlate of this expression was obtained by our findings that the combination of anti-B7-1 and anti-B7-2 monoclonal antibodies was more effective than each separately in blocking allogeneic T cell activation (proliferation and cytokine secretion) by Hodgkin's disease-derived cell lines as stimulators. The possible role of B7-1 and B7-2 expression for the course and symptomatology of H...Continue Reading

Citations

Apr 15, 2004·Immunology Letters·Herbert Bosshart
Dec 17, 2008·Nature Reviews. Cancer·Ralf Küppers
Dec 17, 2009·Hematology·Ralf Küppers
Dec 28, 1999·Medical and Pediatric Oncology·S W Van GoolJ L Ceuppens
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Eva Pizzoferrato
Dec 20, 2017·Frontiers in Immunology·Zijun Y Xu-MonetteKen H Young
Jun 25, 2002·Oncogene·Mark Wunderlich, Steven J Berberich
May 29, 2002·Oncogene·Shinichi KitadaJohn C Reed
Nov 10, 2017·Blood·Zijun Y Xu-MonetteKen H Young
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George Z RassidakisAndreas H Sarris
Aug 27, 2019·Medicinal Research Reviews·Rui ChenKhaled Barakat
Sep 1, 2015·Journal of Leukocyte Biology·Frederik Wein, Ralf Küppers
Jul 2, 2021·Journal of Clinical and Experimental Hematopathology : JCEH·Masaharu KawashimaAi Kotani

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.