PMID: 11903740Mar 21, 2002Paper

Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse

Journal of Gastroenterology and Hepatology
R H GroseA W Hohmann

Abstract

T-cell activation, mediated by the interaction with major histocompatibility complex (MHC)-peptide complexes and B7 costimulatory molecules on antigen-presenting cells, is an essential event in the pathogenesis of inflammatory bowel disease (IBD). We investigated the expression of B7 costimulatory molecules on cells in the colon in an experimental mouse model of IBD to determine whether the B7/ligand interaction could provide a target for therapeutic intervention in IBD. Experimental colitis was induced in mice by oral consumption of water substituted with 5% dextran sulfate sodium (DSS). Mice (n=4) were killed 1, 2, 3, 4 and 7 days after commencing DSS consumption, and colonic tissue was collected and examined immunohistochemically for T cells, B cells, macrophages and cells expressing B7-1 or B7-2. Compared to control mice drinking water, macrophage numbers in the colonic epithelium were elevated sevenfold by day 1 and T cells were elevated threefold by day 3 following commencement of DSS consumption. Numbers of infiltrating B7-positive (B7+) cells were not significantly elevated until day 7 when B7-1+, B7-2+ cells and macrophages were increased 20-fold compared to normal mice. These results demonstrate that an initial and ra...Continue Reading

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Citations

Nov 2, 2015·Cytokine·Udai P SinghPrakash S Nagarkatti
Aug 9, 2002·Journal of Gastroenterology and Hepatology·Michael C Grimm
Jan 8, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia MelgarErik Michaëlsson

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