Expression of BAFF-R, but not BAFF, is an independent prognostic factor in diffuse large B-cell lymphoma patients treated with R-CHOP

Annals of Hematology
Yu WangZhi-Ming Li

Abstract

B-cell activating factor (BAFF) and BAFF-receptor (BAFF-R) play crucial roles in the progression of malignant B-cells. The aim of the present study was to evaluate the expression profiles and the clinical significance of BAFF and BAFF-R in diffuse large B-cell lymphoma (DLBCL). Paraffin-embedded specimens from 136 patients with newly diagnosed DLBCL, treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP), were examined for BAFF and BAFF-R expression by immunohistochemistry. BAFF and BAFF-R were expressed in 72.1 % (98/136) and 47.1 % (64/136) of the DLBCL tissues, respectively. Negative BAFF-R expression was significantly correlated with elevated serum lactate dehydrogenase (LDH) levels (P = 0.036), an International Prognostic Index (IPI) score of 2 or higher (P < 0.001), and a poor revised IPI (R-IPI) risk score (P = 0.043). The complete response rate after R-CHOP was higher in patients with positive BAFF-R expression than in those with negative BAFF-R expression (73.4 vs. 56.9 %, P = 0.045). Negative expression of BAFF-R, but not of BAFF, was significantly associated with inferior progression-free survival (PFS; P = 0.020) and overall survival (OS; P = 0.028). Only negativ...Continue Reading

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Citations

Jun 9, 2016·Advances in Anatomic Pathology·Penelope KorkolopoulouMaria Ioannou
Dec 4, 2016·Hematology·Bertrand Coiffier, Clémentine Sarkozy
Apr 2, 2019·Oncology Letters·Xiao-Jun GeJun-Yao Jiang
May 8, 2020·International Journal of Molecular Sciences·Valentina GiudiceCarmine Selleri
Dec 20, 2018·Annals of Clinical and Translational Neurology·Hironori MizutaniYukio Ando
Feb 6, 2020·Anti-cancer Agents in Medicinal Chemistry·Feifei SunXin Wang

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