Expression of basic fibroblast growth factor, endothelial mitogenic activity, and angiotensin II type-1 receptors in the ovine placenta during the third trimester of pregnancy

Biology of Reproduction
J ZhengR R Magness

Abstract

To evaluate expression of basic fibroblast growth factor (FGF), endothelial mitogenic activity, and angiotensin II type-1 receptors (AT1r), as well as the role of angiotensin II (ANG II) in regulating basic FGF production/secretion, placentae were obtained from ewes on Days 110, 120, 130, and 142 of pregnancy and were separated into fetal cotyledonary (COT) and intercotyledonary (ICOT), as well as maternal caruncular (CAR) and intercaruncular (ICAR) components. Using immunohistochemistry, basic FGF and AT1r were found for the most part to be colocalized in all placental components, primarily in epithelium, stroma, endothelium, and vascular smooth muscle. Changes in basic FGF levels in placental explant-conditioned media were observed in fetal, but not maternal, components. In COT, basic FGF levels increased 2.4-fold (r2 = 0.48, p < 0.04) from Day 110 to 130 and then declined at term. In ICOT, basic FGF levels increased 6.4-fold (r2 = 0.33, p < 0.05) from Day 110 to 142. The rank order of averaged basic FGF levels was COT > CAR > ICOT = ICAR (p < 0.05). Endothelial mitogenic activity of conditioned media was observed in COT from Day 130 pregnant ewes (232.5 +/- 38.7% of control; p < 0.05) but not in other components, and it was ...Continue Reading

Citations

Nov 23, 2011·The Journal of Endocrinology·Kai Wang, Jing Zheng
Apr 12, 2011·Folia Histochemica Et Cytobiologica·M ChruscielA Andronowska
Aug 29, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Dong-Bao Chen, Jing Zheng
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Apr 25, 2001·Biology of Reproduction·C SheppardR R Magness
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Jan 20, 2021·Physiological Reports·Jayonta BhattacharjeeKristi B Adamo
Aug 13, 1999·The American Journal of Physiology·H ItohR R Magness

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